Histone H2A.J Inhibitors
Histone H2A.J inhibitors belong to a specialized chemical class designed to selectively target and modulate the function of H2A.J histone proteins. H2A.J, a variant within the histone family, plays a distinctive role in the intricate regulation of chromatin structure and gene expression. As an integral component of nucleosomes, H2A.J contributes to the compaction of DNA and influences the dynamics of gene regulation within the cellular context. The inhibitors developed for Histone H2A.J are meticulously crafted to interact with the specific molecular structure of this histone variant, with the aim of disrupting its normal interactions within the nucleosome and potentially influencing the broader chromatin landscape.
The molecular architecture of Histone H2A.J inhibitors is precisely tailored to engage with specific binding sites on H2A.J, inducing changes in its conformation and dynamics. This interaction holds the potential to impact the accessibility of DNA, thereby influencing the regulatory processes governing gene expression. In laboratory investigations, these inhibitors serve as invaluable tools, allowing researchers to delve into the nuanced roles of H2A.J in diverse cellular processes and contributing to a deeper understanding of chromatin biology. By manipulating the function of H2A.J, scientists aim to unravel the intricate mechanisms of gene regulation, shedding light on the broader implications of epigenetic processes for cellular function and development. The study of Histone H2A.J inhibitors stands at the forefront of advancing our understanding of chromatin dynamics and the finely tuned orchestration of gene expression within the cellular milieu.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound can inhibit DNA methyltransferases, potentially leading to reduced methylation and altered gene expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As a histone deacetylase inhibitor, it can affect chromatin structure and gene expression patterns. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor, which may change histone acetylation status and influence gene expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
It acts as a histone deacetylase inhibitor, potentially affecting transcription and chromatin architecture. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
This compound is a DNA methyltransferase inhibitor, which may disrupt methylation-dependent gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Similar to 5-azacytidine, it inhibits DNA methylation, which could lead to altered gene regulation. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
It binds to DNA and affects transcription factor binding, potentially altering gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to intercalate into DNA, which may affect DNA replication and gene expression. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Interacts with DNA and inhibits RNA polymerase, leading to decreased gene transcription. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
It has been shown to inhibit the transcription of various genes, potentially affecting global gene expression. | ||||||