Date published: 2025-9-25

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Heterobifunctional Crosslinkers

Santa Cruz Biotechnology now offers a broad range of heterobifunctional crosslinkers for use in various applications. Heterobifunctional crosslinkers are versatile chemical reagents that possess two different reactive groups, allowing them to link two distinct molecules or surfaces. These crosslinkers are crucial in scientific research for studying and manipulating molecular interactions, creating conjugates, and developing advanced biomaterials. Researchers utilize heterobifunctional crosslinkers to investigate protein-protein, protein-DNA, and protein-ligand interactions, providing insights into cellular signaling pathways, structural biology, and enzymatic functions. They are also used to immobilize biomolecules on various surfaces for biosensor development, drug delivery systems, and diagnostic assays. The ability to selectively and efficiently join different molecules makes these crosslinkers invaluable for designing complex molecular architectures and enhancing the functionality of biomaterials. By providing a comprehensive selection of high-quality heterobifunctional crosslinkers, Santa Cruz Biotechnology supports cutting-edge research in biochemistry, molecular biology, and materials science. These products enable scientists to achieve precise and reproducible results, driving advancements in our understanding of molecular interactions and the development of innovative biotechnological applications. View detailed information on our available heterobifunctional crosslinkers by clicking on the product name.

Items 21 to 30 of 56 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

N-Succinimidyloxycarbonylethyl Methanethiosulfonate

385399-11-1sc-212284
10 mg
$360.00
(0)

N-Succinimidyloxycarbonylethyl Methanethiosulfonate is a heterobifunctional reagent featuring a succinimidyl ester and a methanethiosulfonate group. The succinimidyl moiety is highly reactive towards amines, promoting efficient conjugation, while the methanethiosulfonate group selectively reacts with thiols, forming stable thioether bonds. This dual reactivity enables the formation of diverse bioconjugates and facilitates intricate molecular designs, enhancing its versatility in various applications.

N-Succinimidyloxycarbonylpropyl Methanethiosulfonate

690632-55-4sc-219231
10 mg
$360.00
(0)

N-Succinimidyloxycarbonylpropyl Methanethiosulfonate is a heterobifunctional compound characterized by its unique reactivity profile. The succinimidyl component exhibits a strong affinity for nucleophilic amines, enabling rapid and selective conjugation. Meanwhile, the methanethiosulfonate group engages in specific interactions with thiols, leading to the formation of robust thioether linkages. This dual functionality allows for precise molecular engineering and the creation of complex biomolecular architectures.

6-Maleimidohexanoic acid N-hydroxysuccinimide ester

55750-63-5sc-239101
1 g
$88.00
(0)

6-Maleimidohexanoic acid N-hydroxysuccinimide ester is a heterobifunctional reagent distinguished by its dual reactive sites. The maleimide moiety selectively reacts with thiol groups, facilitating the formation of stable thioether bonds, while the N-hydroxysuccinimide (NHS) ester readily reacts with amines, promoting efficient conjugation. This unique combination of reactivity enables versatile applications in bioconjugation and the design of intricate molecular constructs, enhancing specificity and stability in various interactions.

N-Succinimidyl (4-Iodoacetyl)-aminobenzoate

72252-96-1sc-219221
10 mg
$300.00
(0)

N-Succinimidyl (4-Iodoacetyl)-aminobenzoate is a heterobifunctional reagent characterized by its unique reactivity profile. The iodoacetyl group exhibits a strong electrophilic nature, allowing for rapid acylation of nucleophiles, particularly amines and thiols. Meanwhile, the succinimidyl ester facilitates efficient coupling with primary amines, promoting stable linkages. This dual functionality enables precise manipulation of biomolecules, enhancing the specificity of conjugation reactions and expanding the toolkit for molecular engineering.

3-(2-Pyridyldithio)propanoic Acid Hydrazide

115616-51-8sc-209452
5 mg
$360.00
(0)

3-(2-Pyridyldithio)propanoic Acid Hydrazide is a heterobifunctional compound notable for its dual reactivity. The pyridyldithio moiety provides a unique thiol-reactive site, enabling selective disulfide bond formation, while the hydrazide group facilitates nucleophilic attack on carbonyls, promoting efficient conjugation with aldehydes and ketones. This combination allows for versatile cross-linking and labeling strategies, enhancing the precision of molecular interactions in various applications.

Sulfo-N-succinimidyl (N-Iodoacetyl)aminobenzoate

144650-93-1sc-358557
25 mg
$300.00
(0)

Sulfo-N-succinimidyl (N-Iodoacetyl)aminobenzoate is a heterobifunctional reagent characterized by its unique ability to engage in selective labeling and cross-linking. The sulfonate group enhances solubility and reactivity, while the iodoacetyl moiety acts as a potent electrophile, facilitating covalent bond formation with nucleophilic sites on proteins and other biomolecules. This dual functionality allows for precise manipulation of molecular interactions, enabling tailored experimental designs in biochemical research.

N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate

sc-219226
10 mg
$300.00
(0)

N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate is a heterobifunctional compound distinguished by its dual reactive sites, which enable specific conjugation and cross-linking. The maleimide group exhibits a strong affinity for thiol groups, promoting stable thioether linkages, while the succinimidyl ester facilitates amine coupling. This unique combination allows for versatile modifications of biomolecules, enhancing the precision of molecular assembly and interaction studies in various biochemical applications.

N-Succinimidyl Bromoacetate

42014-51-7sc-212278
100 mg
$280.00
(0)

N-Succinimidyl Bromoacetate is a heterobifunctional reagent characterized by its reactive bromoacetate and succinimidyl ester moieties. The bromoacetate group readily engages in nucleophilic substitution reactions, allowing for efficient labeling of amines and thiols. This compound's ability to form stable covalent bonds enhances its utility in creating complex biomolecular architectures. Its distinct reactivity profiles enable precise control over conjugation strategies, facilitating innovative approaches in biochemical research.

N-Succinimidyl 3-(Bromoacetamido)propionate

57159-62-3sc-212276
10 mg
$360.00
(0)

N-Succinimidyl 3-(Bromoacetamido)propionate is a heterobifunctional compound featuring a bromoacetamido group and a succinimidyl moiety. The bromoacetamido segment exhibits high reactivity towards nucleophiles, enabling selective conjugation with amines and thiols. This compound's unique structure allows for the formation of stable linkages, promoting the development of intricate molecular constructs. Its distinct reactivity patterns facilitate tailored modifications in various biochemical applications.

3-N-Maleimidobenzoic Acid N-Succinimidyl Ester

58626-38-3sc-209654
250 mg
$300.00
(0)

3-N-Maleimidobenzoic Acid N-Succinimidyl Ester is a heterobifunctional reagent characterized by its maleimide and succinimidyl functionalities. The maleimide group exhibits a strong affinity for thiol groups, enabling efficient and specific conjugation, while the succinimidyl ester facilitates reactions with amines. This dual reactivity allows for versatile cross-linking strategies, enhancing the formation of complex biomolecular architectures and enabling precise modifications in diverse experimental contexts.