HECTD3 Inhibitors
HECTD3 inhibitors belong to a class of small molecules that specifically target the HECTD3 protein, which is a member of the E3 ubiquitin ligase family. The term "HECTD3" stands for "Homologous to the E6-AP Carboxyl Terminus Domain 3," and this protein plays a crucial role in the ubiquitin-proteasome system (UPS), a highly regulated cellular pathway responsible for protein degradation. HECTD3 is an E3 ligase, meaning it facilitates the transfer of ubiquitin molecules to target proteins, marking them for degradation by the proteasome. The ubiquitin-proteasome system is a fundamental cellular process responsible for maintaining protein homeostasis and regulating various cellular functions, including cell cycle progression, DNA repair, and the degradation of misfolded or damaged proteins.
HECTD3 inhibitors, as the name suggests, are compounds designed to inhibit the activity of HECTD3. By interfering with HECTD3's function, these inhibitors disrupt the ubiquitination process, leading to the stabilization of specific proteins that would otherwise be targeted for degradation. This targeted inhibition can have significant implications in various cellular processes and pathways, potentially influencing the stability and activity of proteins involved in cell signaling, DNA repair, and protein turnover. Understanding the role of HECTD3 inhibitors in modulating these pathways could provide valuable insights into the mechanisms underlying various cellular functions and may open up avenues for further research.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a peptide aldehyde that inhibits proteasome and calpains, potentially increasing the levels of ubiquitinated proteins and indirectly affecting HECTD3's substrate availability. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
Pyr-41 is a selective inhibitor of E1 ubiquitin-activating enzyme, potentially reducing ubiquitin conjugation and indirectly influencing HECTD3 activity. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN4924 is a NEDD8-activating enzyme inhibitor, which can prevent neddylation of cullin proteins and may indirectly alter HECTD3 mediated ubiquitination processes. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a specific inhibitor of the proteasome, leading to increased ubiquitinated proteins, which can affect the regulatory roles of HECTD3. | ||||||
IU1 | 314245-33-5 | sc-361215 sc-361215A sc-361215B | 10 mg 50 mg 100 mg | $138.00 $607.00 $866.00 | 2 | |
IU1 is a specific inhibitor of the deubiquitinating enzyme USP14, which can influence the turnover of ubiquitinated proteins, affecting HECTD3's role in protein degradation. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is a proteasome inhibitor used to induce accumulation of polyubiquitinated proteins, which can have an indirect effect on HECTD3 function. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin is a selective proteasome inhibitor that leads to the accumulation of ubiquitinated proteins, potentially altering HECTD3 mediated processes. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide, through its metabolites, can inhibit the E3 ubiquitin ligase cereblon, potentially affecting protein ubiquitination pathways in which HECTD3 is involved. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 disrupts the interaction between MDM2 and p53, potentially affecting ubiquitination pathways and indirectly influencing the activity of HECTD3. | ||||||
PR 619 | 2645-32-1 | sc-476324 sc-476324A sc-476324B | 1 mg 5 mg 25 mg | $77.00 $188.00 $431.00 | 1 | |
PR-619 is a broad-spectrum deubiquitinating enzyme inhibitor, which can lead to increased ubiquitinated protein levels, thereby affecting HECTD3's role in protein degradation. | ||||||