HDAC6 Inhibitors
Santa Cruz Biotechnology now offers a broad range of HDAC6 Inhibitors. Histone deacetylase proteins (HDACs) are a class of enzymes that remove acetyl groups (O=C-CH3) from an <ε>-N-acetyl lysine amino acid on a histone, allowing histones to wrap DNA more tightly. The deacetylation of histones is associated with transcriptional silencing. Histone deacetylase inhibitors (HDIs) have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptic. HDIs are studied as a treatment for neurodegenerative diseases and have a potential for cancer therapy. HDAC6 Inhibitors offered by Santa Cruz inhibit HDAC6 and, in some cases, other chromatin remodeling and transcription regulation related proteins. View detailed HDAC6 Inhibitor specifications, including HDAC6 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PPM-18 | 65240-86-0 | sc-203216 | 10 mg | $220.00 | ||
PPM-18 is a selective inhibitor of HDAC6, distinguished by its unique ability to engage in π-π stacking interactions with aromatic residues within the enzyme's active site. This compound alters the electrostatic environment, enhancing binding affinity and promoting a conformational shift that stabilizes the inactive form of HDAC6. Kinetic studies indicate a non-competitive inhibition profile, allowing for nuanced regulation of histone acetylation and downstream effects on gene expression and cellular processes. | ||||||