HDAC6 Inhibitors
Santa Cruz Biotechnology now offers a broad range of HDAC6 Inhibitors. Histone deacetylase proteins (HDACs) are a class of enzymes that remove acetyl groups (O=C-CH3) from an <ε>-N-acetyl lysine amino acid on a histone, allowing histones to wrap DNA more tightly. The deacetylation of histones is associated with transcriptional silencing. Histone deacetylase inhibitors (HDIs) have a long history of use in psychiatry and neurology as mood stabilizers and anti-epileptic. HDIs are studied as a treatment for neurodegenerative diseases and have a potential for cancer therapy. HDAC6 Inhibitors offered by Santa Cruz inhibit HDAC6 and, in some cases, other chromatin remodeling and transcription regulation related proteins. View detailed HDAC6 Inhibitor specifications, including HDAC6 Inhibitor CAS number, molecular weight, molecular formula and chemical structure, by clicking on the product name.
Items 1 to 10 of 21 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a classic HDAC inhibitor and can inhibit HDAC6, potentially down-regulating its expression or activity | ||||||
MC 1568 | 852475-26-4 | sc-362767 sc-362767A | 10 mg 50 mg | $179.00 $566.00 | 4 | |
MC 1568 functions as a selective HDAC6 inhibitor, distinguished by its unique molecular interactions that facilitate a strong affinity for the enzyme's active site. This compound exhibits a remarkable ability to disrupt the enzyme's catalytic mechanism through specific hydrogen bonding and hydrophobic interactions. Its kinetic profile reveals a rapid onset of inhibition, leading to immediate alterations in cellular signaling pathways, while maintaining a low propensity for off-target effects. | ||||||
Tubacin | 537049-40-4 | sc-362815 sc-362815A sc-362815B sc-362815C sc-362815D | 1 mg 5 mg 50 mg 500 mg 1 g | $197.00 $429.00 $4249.00 $10543.00 $13674.00 | 8 | |
Tubacin is a selective HDAC6 inhibitor, specifically targeting its tubulin deacetylation activity. | ||||||
HDAC6 Inhibitor Inhibitor | 1045792-66-2 | sc-223877 sc-223877A | 500 µg 1 mg | $62.00 $86.00 | 5 | |
A potent HDAC6 inhibitor, potentially down-regulating its expression or activity. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
SAHA is a pan-HDAC inhibitor, affecting HDAC6 among other HDACs. | ||||||
Tubastatin A (trifluoroacetate salt) | 1239262-52-2 | sc-364640 sc-364640A sc-364640B | 1 mg 5 mg 10 mg | $77.00 $230.00 $326.00 | 2 | |
Tubastatin A (trifluoroacetate salt) is a selective inhibitor of HDAC6, characterized by its unique binding dynamics that enhance its interaction with the enzyme's active site. This compound engages in specific electrostatic and van der Waals interactions, promoting a stable complex formation. Its inhibition kinetics demonstrate a time-dependent effect, allowing for nuanced modulation of protein acetylation levels, which can influence various cellular processes without significant cross-reactivity with other HDAC isoforms. | ||||||
1-Naphthohydroxamic Acid | 6953-61-3 | sc-364388 sc-364388A | 5 mg 25 mg | $85.00 $330.00 | ||
1-Naphthohydroxamic Acid exhibits a distinctive mechanism of action as an HDAC6 inhibitor, characterized by its ability to form strong hydrogen bonds with key residues in the enzyme's active site. This compound's structural features facilitate unique π-π stacking interactions, enhancing its binding affinity. Its kinetic profile reveals a rapid onset of inhibition, allowing for precise regulation of histone acetylation, thereby influencing cellular signaling pathways with minimal interference in other HDAC activities. | ||||||
Tubastatin A hydrochloride | 1310693-92-5 | sc-364641 sc-364641A | 10 mg 50 mg | $190.00 $419.00 | 3 | |
Tubastatin A hydrochloride functions as a selective HDAC6 inhibitor, distinguished by its unique ability to engage in hydrophobic interactions with the enzyme's active site. Its structural conformation allows for specific electrostatic interactions, enhancing its binding specificity. The compound exhibits a favorable kinetic profile, demonstrating a sustained inhibitory effect that modulates protein acetylation dynamics, thereby influencing cellular processes without broadly affecting other histone deacetylases. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat inhibits multiple HDACs, including HDAC6, potentially impacting its expression or activity. | ||||||
Droxinostat | 99873-43-5 | sc-364485 sc-364485A | 5 mg 25 mg | $85.00 $454.00 | 1 | |
Droxinostat acts as a selective inhibitor of HDAC6, characterized by its unique binding affinity that stems from its ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. This compound exhibits a distinct mechanism of action, promoting the accumulation of acetylated proteins by disrupting the deacetylation process. Its kinetic properties suggest a rapid onset of inhibition, allowing for precise modulation of cellular signaling pathways while maintaining selectivity for HDAC6 over other isoforms. | ||||||