HACE1 Activators
The class of HACE1 activators, as conceptualized in the table, is characterized by their ability to influence cellular pathways and environments that indirectly support or enhance HACE1 activity. These chemicals generally work by modulating key signaling pathways, transcription factors, or cellular stress responses, thereby creating a conducive environment for HACE1's functional roles. Compounds such as Insulin and Metformin activate pathways like PI3K/Akt and AMPK respectively, which are central to cellular metabolism and energy balance. The activation of these pathways can foster a cellular environment that supports HACE1's role in protein quality control and cellular homeostasis. Similarly, natural compounds like Resveratrol and Curcumin, known for their roles in enhancing cellular resilience to stress, can indirectly facilitate HACE1's function in stress response mechanisms.
Another significant aspect of these activators is their role in modulating transcription factors and gene expression. For instance, Retinoic Acid influences gene expression, which can lead to an upregulation of cellular mechanisms where HACE1 is involved. Vitamin D3, through its hormonal action, also affects cellular signaling and could support HACE1 function in various cellular processes. In summary, the chemical class of HACE1 activators encompasses a range of compounds that indirectly enhance HACE1's activity by influencing key cellular pathways, stress responses, and metabolic processes. These activators do not directly target HACE1 but create a cellular milieu that supports or upregulates HACE1's roles in protein ubiquitination, cellular stress responses, and maintaining cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin, through its receptor signaling, activates PI3K/Akt pathway, which is known to influence a variety of cellular processes including those related to ubiquitination and proteostasis. This activation can lead to an upregulated cellular environment that supports HACE1 function, particularly in its role in protein quality control. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which is involved in cellular stress responses and longevity. Activation of SIRT1 can lead to enhanced cellular resilience mechanisms where HACE1 plays a role, potentially upregulating HACE1 activity in response to oxidative stress. | ||||||
Metformin | 657-24-9 | sc-507370 | 10 mg | $77.00 | 2 | |
Metformin activates AMPK, a key regulator of cellular energy homeostasis. AMPK activation can enhance cellular stress responses and autophagy processes, potentially supporting HACE1 function in maintaining protein quality and cellular homeostasis. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is known to modulate NF-κB signaling. This modulation can lead to altered inflammatory responses and cellular stress pathways, potentially creating a cellular context that supports or enhances HACE1 activity, particularly in stress response and inflammation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, is known to influence multiple signaling pathways, including those related to oxidative stress and inflammation. This broad modulation can indirectly support HACE1's role in cellular stress responses and protein quality control. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates Nrf2, a key regulator in cellular oxidative stress response. This activation can enhance the antioxidant response, potentially supporting HACE1 function in cellular protection mechanisms against oxidative stress. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid influences gene expression through its receptors. This can lead to changes in cellular differentiation processes, potentially supporting HACE1 function in protein ubiquitination and cell cycle regulation. | ||||||
Pioglitazone | 111025-46-8 | sc-202289 sc-202289A | 1 mg 5 mg | $54.00 $123.00 | 13 | |
Pioglitazone, a PPAR-γ agonist, modulates lipid metabolism and insulin sensitivity. This modulation can indirectly influence cellular stress responses and energy metabolism, potentially supporting HACE1 activity. | ||||||
Troglitazone | 97322-87-7 | sc-200904 sc-200904B sc-200904A | 5 mg 10 mg 25 mg | $108.00 $200.00 $426.00 | 9 | |
Troglitazone, another PPAR-γ agonist, similarly affects lipid metabolism and insulin sensitivity. Its action can create a metabolic environment that indirectly supports HACE1 function in cellular stress and energy homeostasis. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $70.00 $160.00 $290.00 | 2 | |
Cholecalciferol, through its hormonal action, regulates calcium homeostasis and bone metabolism. This regulation can influence cellular signaling pathways, potentially supporting HACE1 function in cell signaling and stress response. | ||||||