H2-M1 inhibitors are a specific class of chemical compounds designed to modulate the activity of the H2-M1 protein. H2-M1, also known as histocompatibility 2, M region locus 1, is a protein that is part of the major histocompatibility complex (MHC) in mice, which plays a critical role in the immune system. The primary function of H2-M1 is to present antigenic peptides to T cells, facilitating the recognition of foreign pathogens by the immune system. This process is essential for the body's ability to mount an immune response against infections. H2-M1 inhibitors are developed with the primary goal of selectively interacting with the H2-M1 protein, potentially influencing its antigen-presenting activity and, consequently, impacting the immune response against specific antigens.
Typically, H2-M1 inhibitors consist of small molecules or chemical compounds specifically designed to bind to H2-M1, targeting either its active site or allosteric sites. This interaction can lead to the modulation of H2-M1's behavior, potentially affecting its ability to present antigenic peptides to T cells. Researchers are primarily interested in elucidating the molecular mechanisms and functions of H2-M1 in the context of antigen presentation and immune response. The development of H2-M1 inhibitors represents an ongoing area of research within the field of immunology and molecular pharmacology, contributing to our understanding of the immune system and its role in recognizing and defending against foreign invaders.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine can be incorporated into DNA, where it inhibits DNA methyltransferases, potentially leading to the demethylation and suppression of gene expression. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Hydralazine is hypothesized to inhibit DNA methylation, which might result in the altered expression of genes through epigenetic mechanisms. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a non-nucleoside DNA methyltransferase inhibitor, which may prevent methylation of gene promoters, influencing gene expression levels. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine acts as a cytidine analog that inhibits DNA methyltransferase, potentially reducing gene expression through DNA demethylation. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can modulate the activity of nucleic acid-related enzymes, potentially affecting transcription and gene expression. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
This compound has been shown to inhibit NF-κB, which could downregulate genes involved in immune responses. | ||||||
Sinefungin | 58944-73-3 | sc-203263 sc-203263B sc-203263C sc-203263A | 1 mg 100 mg 1 g 10 mg | $266.00 $5100.00 $39576.00 $690.00 | 4 | |
Sinefungin is an adenosine analog that can inhibit methyltransferase enzymes, potentially affecting gene expression regulation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that may also affect DNA methylation and histone acetylation, altering gene expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide can inhibit NF-κB, which may decrease the transcription of certain genes involved in immune regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is known to modulate several signaling pathways and may influence gene expression by affecting transcription factor activity. | ||||||