Date published: 2026-2-14

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H2-Dk Inhibitors

H2-Dk inhibitors are a class of chemical compounds that target the H2-Dk molecule, which is a major histocompatibility complex (MHC) class I protein in mice. The H2-Dk molecule plays an essential role in the immune system, specifically in antigen presentation to cytotoxic T lymphocytes. It is responsible for presenting endogenous peptides, including viral or intracellular proteins, to T cells, which is crucial for the immune recognition of infected or abnormal cells. H2-Dk inhibitors function by interfering with this antigen presentation process, either by affecting the loading of peptides onto the H2-Dk molecule or by preventing the stable expression of H2-Dk on the cell surface.

The mode of action of H2-Dk inhibitors can vary depending on their molecular structure. Some inhibitors may disrupt the peptide binding groove of the H2-Dk molecule, making it difficult for peptides to be loaded and presented to T cells. Others may interfere with the assembly or transport of the H2-Dk molecule to the cell surface, thus reducing its availability for interaction with T cells. These inhibitors are valuable in studying the regulation of immune responses, particularly in understanding how alterations in antigen presentation can affect T cell activation and immune recognition. The specificity of these inhibitors for the H2-Dk molecule is critical for their effectiveness, as they must precisely target the MHC class I molecules without affecting other proteins involved in immune functions. This class of compounds provides important insights into the dynamics of antigen presentation and the molecular pathways that govern immune recognition processes in mammals.

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Items 1 to 10 of 12 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Curcumin

458-37-7sc-200509
sc-200509A
sc-200509B
sc-200509C
sc-200509D
sc-200509F
sc-200509E
1 g
5 g
25 g
100 g
250 g
1 kg
2.5 kg
$37.00
$69.00
$109.00
$218.00
$239.00
$879.00
$1968.00
47
(1)

Curcumin may downregulate the expression of H2-Dk by suppressing the activation of NF-κB, which is essential for the transcription of H2-Dk genes in immune system functioning.

Resveratrol

501-36-0sc-200808
sc-200808A
sc-200808B
100 mg
500 mg
5 g
$80.00
$220.00
$460.00
64
(2)

Resveratrol could decrease H2-Dk levels by inhibiting the NF-κB pathway, thus leading to a reduction in the transcriptional activity of genes within the H2 complex.

Sodium Salicylate

54-21-7sc-3520
sc-3520A
sc-3520B
sc-3520C
1 g
25 g
500 g
1 kg
$10.00
$26.00
$82.00
$139.00
8
(1)

Sodium Salicylate may reduce the expression of H2-Dk by directly inhibiting the IκB kinase complex, leading to decreased activation of NF-κB and subsequent downregulation of MHC class I gene expression.

(−)-Epigallocatechin Gallate

989-51-5sc-200802
sc-200802A
sc-200802B
sc-200802C
sc-200802D
sc-200802E
10 mg
50 mg
100 mg
500 mg
1 g
10 g
$43.00
$73.00
$126.00
$243.00
$530.00
$1259.00
11
(1)

Epigallocatechin Gallate has the potential to decrease H2-Dk expression through the inhibition of NF-κB DNA binding activity, thereby reducing the transcription of the H2-Dk gene involved in antigen presentation.

Wogonin, S. baicalensis

632-85-9sc-203313
10 mg
$200.00
8
(1)

Wogonin might suppress H2-Dk expression by directly inhibiting the phosphorylation and degradation of IκB, which prevents NF-κB from translocating to the nucleus and initiating H2-Dk gene transcription.

BAY 11-7082

19542-67-7sc-200615B
sc-200615
sc-200615A
5 mg
10 mg
50 mg
$62.00
$85.00
$356.00
155
(1)

Bay 11-7082 could inhibit the phosphorylation of IκBα, resulting in decreased nuclear translocation of NF-κB and a subsequent reduction in H2-Dk mRNA and protein levels.

Aspirin

50-78-2sc-202471
sc-202471A
5 g
50 g
$20.00
$42.00
4
(1)

Aspirin may attenuate H2-Dk expression by irreversibly acetylating the NF-κB signaling pathway components, leading to diminished transcriptional activity of the H2-Dk locus.

Parthenolide

20554-84-1sc-3523
sc-3523A
50 mg
250 mg
$81.00
$306.00
32
(2)

Parthenolide potentially reduces H2-Dk expression by directly binding to and inhibiting the IκB kinase complex, thereby preventing NF-κB from initiating transcription of the H2-Dk gene.

Andrographolide

5508-58-7sc-205594
sc-205594A
50 mg
100 mg
$15.00
$40.00
7
(1)

Andrographolide could lead to a decrease in H2-Dk expression by covalently modifying cysteine residues in the NF-κB signaling cascade, thus preventing the transcription of genes within the H2 complex.

Celastrol, Celastrus scandens

34157-83-0sc-202534
10 mg
$158.00
6
(1)

Celastrol may downregulate the expression of H2-Dk by hindering the heat shock protein 90 (Hsp90) which is associated with the stability and function of the IκB kinase complex, thereby reducing NF-κB-mediated transcription.