H2-Dk Inhibitors
H2-Dk inhibitors are a class of chemical compounds that target the H2-Dk molecule, which is a major histocompatibility complex (MHC) class I protein in mice. The H2-Dk molecule plays an essential role in the immune system, specifically in antigen presentation to cytotoxic T lymphocytes. It is responsible for presenting endogenous peptides, including viral or intracellular proteins, to T cells, which is crucial for the immune recognition of infected or abnormal cells. H2-Dk inhibitors function by interfering with this antigen presentation process, either by affecting the loading of peptides onto the H2-Dk molecule or by preventing the stable expression of H2-Dk on the cell surface.
The mode of action of H2-Dk inhibitors can vary depending on their molecular structure. Some inhibitors may disrupt the peptide binding groove of the H2-Dk molecule, making it difficult for peptides to be loaded and presented to T cells. Others may interfere with the assembly or transport of the H2-Dk molecule to the cell surface, thus reducing its availability for interaction with T cells. These inhibitors are valuable in studying the regulation of immune responses, particularly in understanding how alterations in antigen presentation can affect T cell activation and immune recognition. The specificity of these inhibitors for the H2-Dk molecule is critical for their effectiveness, as they must precisely target the MHC class I molecules without affecting other proteins involved in immune functions. This class of compounds provides important insights into the dynamics of antigen presentation and the molecular pathways that govern immune recognition processes in mammals.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate the expression of H2-Dk by suppressing the activation of NF-κB, which is essential for the transcription of H2-Dk genes in immune system functioning. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol could decrease H2-Dk levels by inhibiting the NF-κB pathway, thus leading to a reduction in the transcriptional activity of genes within the H2 complex. | ||||||
Sodium Salicylate | 54-21-7 | sc-3520 sc-3520A sc-3520B sc-3520C | 1 g 25 g 500 g 1 kg | $10.00 $26.00 $82.00 $139.00 | 8 | |
Sodium Salicylate may reduce the expression of H2-Dk by directly inhibiting the IκB kinase complex, leading to decreased activation of NF-κB and subsequent downregulation of MHC class I gene expression. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Epigallocatechin Gallate has the potential to decrease H2-Dk expression through the inhibition of NF-κB DNA binding activity, thereby reducing the transcription of the H2-Dk gene involved in antigen presentation. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin might suppress H2-Dk expression by directly inhibiting the phosphorylation and degradation of IκB, which prevents NF-κB from translocating to the nucleus and initiating H2-Dk gene transcription. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 could inhibit the phosphorylation of IκBα, resulting in decreased nuclear translocation of NF-κB and a subsequent reduction in H2-Dk mRNA and protein levels. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin may attenuate H2-Dk expression by irreversibly acetylating the NF-κB signaling pathway components, leading to diminished transcriptional activity of the H2-Dk locus. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide potentially reduces H2-Dk expression by directly binding to and inhibiting the IκB kinase complex, thereby preventing NF-κB from initiating transcription of the H2-Dk gene. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide could lead to a decrease in H2-Dk expression by covalently modifying cysteine residues in the NF-κB signaling cascade, thus preventing the transcription of genes within the H2 complex. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol may downregulate the expression of H2-Dk by hindering the heat shock protein 90 (Hsp90) which is associated with the stability and function of the IκB kinase complex, thereby reducing NF-κB-mediated transcription. | ||||||