H2-Aa Activators
H2-Aa Activators are a collection of chemical compounds that, through various biochemical pathways, enhance the functional activity of the H2-Aa protein, a key component of the Major Histocompatibility Complex (MHC) Class II. Forskolin, by increasing intracellular cAMP, indirectly boosts H2-Aa's function by facilitating PKA signaling, which can influence proteins involved in antigen presentation. Sulforaphane, by activating the Nrf2 pathway, may promote the expression of proteasome components, thereby indirectly supporting H2-Aa's antigen processing capabilities. Curcumin and Epigallocatechin gallate (EGCG) modulate the NF-κB pathway, which is crucial for the transcription of immune-related genes, potentially leading to an enhanced role of H2-Aa in presenting antigens. Similarly, Resveratrol's activation of SIRT1 and Anacardic acid's inhibition of histone acetyltransferase can lead to changes in immune gene transcription, indirectly amplifying H2-Aa's antigen presentation.
Further influencing H2-Aa activity are compounds that affect intracellular processes and signaling related to the immune function. Withaferin A may improve H2-Aa's trafficking to the cell surface by altering cytoskeletal organization, while Capsaicin's activation of TRPV1 and the subsequent calcium signaling could facilitate peptide loading of H2-Aa. Indole-3-carbinol's modulation of AhR-mediated transcription might augment the expression of antigen processing components that assist H2-Aa. Celastrol's induction of heat shock responses could enhance the folding and assembly of H2-Aa molecules, improving their antigen presentation capacity. Andrographolide's inhibition of NF-κB signaling, although complex, may indirectly benefit H2-Aa's role in antigen presentation, while β-Caryophyllene's interaction with CB2 receptors could positively affect H2-Aa's involvement in immune surveillance. Together, these H2-Aa activators enhance the protein's functionality by influencing a spectrum of signaling pathways and cellular processes crucial for effective immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which may upregulate the expression of proteasome subunits and immunoproteasome, indirectly enhancing H2-Aa's function in antigen processing. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate the NF-κB pathway, positively influencing the transcription of genes related to immune responses, potentially leading to increased functional activity of H2-Aa in antigen presentation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate proteins and affect the function of transcription factors involved in immune regulation, thereby potentially enhancing the role of H2-Aa in immune responses. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG inhibits NF-κB activation, which may lead to a compensatory increase in the presentation of antigens by MHC Class II molecules such as H2-Aa, enhancing its functional activity. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A can disrupt cytoskeletal organization, which might enhance the intracellular trafficking of H2-Aa to the cell surface, thus increasing its capacity to present antigens. | ||||||
Anacardic Acid | 16611-84-0 | sc-202463 sc-202463A | 5 mg 25 mg | $102.00 $204.00 | 13 | |
Anacardic acid inhibits histone acetyltransferase, which could lead to altered expression of genes involved in the immune response, potentially enhancing H2-Aa's antigen presentation activity. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin activates TRPV1, which may influence the downstream signaling involving calcium influx, possibly enhancing the peptide loading of H2-Aa in the antigen presentation pathway. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol can modulate AhR-mediated transcription, potentially increasing the expression of components of the antigen processing machinery that work in concert with H2-Aa. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol induces heat shock responses, which may enhance the folding and assembly of MHC Class II molecules like H2-Aa, improving its stability and antigen presentation function. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide inhibits NF-κB signaling, which might indirectly enhance H2-Aa's role in antigen presentation due to the complex interplay between NF-κB and immune responses. | ||||||