Gtlf3a Activators
GATA-binding protein 3 Activators areGATA-binding protein 3 Activators are a select group of compounds that enhance the activity of GATA-binding protein 3 through various specific mechanisms. Forskolin, for instance, increases intracellular cAMP, which in turn activates protein kinase A (PKA). PKA phosphorylates proteins that can influence the activity of GATA3, thereby modulating its transcriptional activity. Similarly, Phorbol 12-myristate 13-acetate (PMA) activates protein kinase C (PKC), leading to phosphorylation events that can enhance GATA3's DNA-binding activity. Isoproterenol, a beta-adrenergic receptor agonist, elevates cAMP and activates PKA, which may phosphorylate regulatory proteins of GATA3. Ionomycin, by increasing intracellular calcium, activates calcium-dependent kinases that could phosphorylate and modulate GATA3 function. Epigallocatechin gallate (EGCG) inhibits kinases that might negatively regulate GATA3, potentially alleviating inhibitory effects on GATA3's activity. Dibutyryl cyclic AMP (db-cAMP) acts as a cAMP analog to activate PKA, which may enhance GATA3 function by promoting its interaction with co-activators or by enhancing its DNA binding capability.
A23187 (Calcimycin) raises intracellular calcium, which activates calcium-dependent pathways that may modulate GATA3 function. LY294002, a PI3K inhibitor, and U0126, a MEK inhibitor, can alter downstream signaling pathways, potentially leading to a reduction in negative regulation of GATA3, thereby enhancing its activity. SB203580, by inhibiting p38 MAP kinase, may influence pathways that intersect with GATA3's regulatory network, potentially enhancing its function by reducing negative feedback on its signaling pathways. Chelerythrine, a PKC inhibitor, may shift the balance of cellular signaling towards pathways that activate GATA3 by decreasing the phosphorylation of proteins that negatively regulate GATA3 activity. Lastly, Sildenafil, by inhibiting phosphodiesterase, prevents the breakdown of cAMP and cGMP, leading to their accumulation and potentially enhancing PKA activity, which in turn may lead to the phosphorylation of key proteins in the GATA3 regulatory network, effectively enhancing GATA3 activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a potent activator of protein kinase C (PKC), which plays a role in various signaling pathways. PKC activation can lead to the phosphorylation of proteins that are critical for GATA-binding protein 3 function. This post-translational modification may enhance the DNA-binding activity of GATA3. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentration. Elevated calcium can activate calcium-dependent kinases, which may subsequently phosphorylate and activate proteins that regulate the activity of GATA-binding protein 3, thus enhancing its function in cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a polyphenol found in green tea with kinase inhibitory activity. By inhibiting certain kinases, EGCG could reduce negative regulatory influences on GATA-binding protein 3, potentially enhancing its activity by alleviating inhibition on its functional pathways. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Db-cAMP is a cell-permeable cAMP analog that activates PKA. PKA-mediated phosphorylation of substrates involved in the GATA3 pathway may enhance GATA-binding protein 3 function by promoting its interaction with co-activators or by enhancing its DNA binding capability. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore that increases intracellular calcium concentration, similar to ionomycin. This increase in calcium can activate calcium-dependent signaling pathways that are likely to modulate the function of GATA-binding protein 3 by promoting its activation through post-translational modifications. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of phosphoinositide 3-kinases (PI3K). By inhibiting PI3K, LY294002 can alter downstream signaling pathways, potentially leading to a reduction in negative regulation of GATA-binding protein 3, thereby enhancing its activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. Inhibition of this pathway can lead to changes in the cellular signaling balance that may favor the activation of GATA-binding protein 3 by relieving negative feedback or competitive signaling. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAP kinase. By inhibiting p38 MAPK, SB203580 may influence pathways that intersect or regulate the activity of GATA-binding protein 3, potentially enhancing its function by reducing negative feedback on GATA3's signaling pathways. | ||||||
Chelerythrine chloride | 3895-92-9 | sc-3547 sc-3547A | 5 mg 25 mg | $90.00 $317.00 | 17 | |
Chelerythrine is an inhibitor of PKC. By inhibiting PKC, it may shift the balance of cellular signaling towards pathways that activate GATA-binding protein 3, by decreasing the phosphorylation of proteins that negatively regulate GATA3 activity. | ||||||