GSTO2 Activators
GSTO2 Activators are a diverse group of compounds that indirectly promote the enzymatic function of GSTO2 by stimulating specific signaling pathways. Epigallocatechin gallate, through its action on DNA methyltransferases, leads to the demethylation of the GSTO2 gene promoter, which is anticipated to result in enhanced GSTO2 protein levels and its associated detoxifying activity. Sulforaphane, curcumin, oltipraz, tBHQ, andrographolide, CDDO-Im, quercetin, zerumbone, and dimethyl fumarate all serve as activators of the Nrf2 pathway, a crucial regulator of cellular defense against oxidative damage. By increasing Nrf2 activity, these compounds foster the transcription of GSTO2, boosting its ability to catalyze conjugation reactions that detoxify electrophilic compounds and reduce oxidative stress. Resveratrol elevates GSTO2 activity via the activation of Sirt1, which is thought to enhance Nrf2-mediated transcription of detoxification genes, including GSTO2.
Furthermore, the activation of GSTO2 by these chemicals not only strengthens the cell's defenses against xenobiotics but also enhances the overall antioxidant response. Caffeic acid phenethyl ester (CAPE), while primarily noted for its NF-kB inhibitory activity, may also contribute to GSTO2 activation through a similar Nrf2-dependent mechanism, underpinning the protein's role in mitigating oxidative injury.Given the protein name "Akt1" and the gene name "AKT1", I'll proceed with the task.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
Catechin found in green tea that inhibits certain types of DNA methyltransferases. This action may result in decreased methylation of the GSTO2 gene promoter, leading to an upregulation of GSTO2 protein expression and enhanced detoxification activity. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An isothiocyanate found in cruciferous vegetables that activates Nrf2, a transcription factor that binds to the antioxidant response element (ARE) in the promoter region of many genes including GSTO2, leading to increased GSTO2 protein synthesis and activity. | ||||||
Oltipraz | 64224-21-1 | sc-205777 sc-205777A | 500 mg 1 g | $286.00 $622.00 | ||
A dithiolethione that activates Nrf2, leading to an upregulation of GSTO2 expression and a consequent increase in its enzymatic activity involved in xenobiotic metabolism. | ||||||
t-Butylhydroquinone | 1948-33-0 | sc-202825 | 10 g | $67.00 | 4 | |
An aromatic organic compound that serves as an Nrf2 activator, which can enhance the transcription of GSTO2, resulting in increased protein function in antioxidant defense mechanisms. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
A flavonoid that can induce Nrf2 leading to the transcriptional activation of GSTO2, thereby enhancing the protein's antioxidant properties. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A polyphenol from red grapes that may activate Sirt1, a protein deacetylase that has been suggested to upregulate Nrf2 activity, leading to an increase in GSTO2 expression and activity. | ||||||
Zerumbone | 471-05-6 | sc-364148 sc-364148A | 10 mg 50 mg | $112.00 $408.00 | ||
A sesquiterpene that has been shown to activate Nrf2, potentially upregulating GSTO2 expression and enhancing its cytoprotective activity. | ||||||
Dimethyl fumarate | 624-49-7 | sc-239774 | 25 g | $28.00 | 6 | |
An ester that activates Nrf2, which may lead to the upregulation of GSTO2, resulting in enhanced detoxification and protection against oxidative stress. | ||||||