GPR87 Inhibitors
GPR87 inhibitors belong to a specialized class of chemical compounds designed to target the GPR87 (G-Protein Coupled Receptor 87) protein, which is a member of the G-protein coupled receptor (GPCR) family. GPR87 is a transmembrane receptor found on the surface of various cell types, including certain cancer cells and immune cells. This receptor is known for its involvement in cellular signaling pathways, and its activation can trigger intracellular signaling cascades that regulate various cellular processes. While the exact functions of GPR87 are still being elucidated, it has been implicated in processes such as cell proliferation, migration, and immune responses.
Inhibitors of GPR87 are designed to interact with this receptor and disrupt its activation or downstream signaling. These inhibitors may operate through various mechanisms, such as binding to specific regions of GPR87 or altering its conformation. By inhibiting GPR87, these compounds can interfere with the receptor's ability to respond to its ligands, modulating the signaling events associated with GPR87 activation. Research on GPR87 inhibitors is primarily focused on understanding the molecular mechanisms by which this receptor functions, its role in cellular physiology, and the implications of targeting GPR87 in various pathological conditions, including cancer and immune-related disorders. This research offers insights into the complex world of GPCR-mediated signaling and its impact on cellular behavior and responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sulindac | 38194-50-2 | sc-202823 sc-202823A sc-202823B | 1 g 5 g 10 g | $32.00 $86.00 $150.00 | 3 | |
A compound known to affect various signaling pathways, which may include those regulating GPR87 expression. | ||||||
Cimetidine | 51481-61-9 | sc-202996 sc-202996A | 5 g 10 g | $62.00 $86.00 | 1 | |
A histamine H2 receptor antagonist that modulates cyclic AMP levels, potentially affecting GPCR gene expression. | ||||||
Lovastatin | 75330-75-5 | sc-200850 sc-200850A sc-200850B | 5 mg 25 mg 100 mg | $29.00 $90.00 $339.00 | 12 | |
An HMG-CoA reductase inhibitor that may influence GPCR expression by altering cholesterol synthesis and membrane composition. | ||||||
Fluvastatin, Sodium Salt | 93957-55-2 | sc-202613 sc-202613A sc-202613B | 25 mg 50 mg 100 mg | $93.00 $138.00 $246.00 | 1 | |
Similar to Lovastatin, it may affect GPCR expression through changes in cell membrane lipid composition. | ||||||
Simvastatin | 79902-63-9 | sc-200829 sc-200829A sc-200829B sc-200829C | 50 mg 250 mg 1 g 5 g | $31.00 $89.00 $135.00 $443.00 | 13 | |
Another statin that can have broad effects on cell signaling and potentially on the expression of receptors like GPR87. | ||||||
Rosuvastatin | 287714-41-4 | sc-481834 | 10 mg | $145.00 | 8 | |
By modulating cholesterol biosynthesis, it can indirectly affect cell membrane properties and GPCR expression. | ||||||
Pravastatin | 81093-37-0 | sc-222188 | 50 mg | $408.00 | 1 | |
As a statin, it impacts cholesterol homeostasis and may influence various cell signaling pathways. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Through its action as a PPARα agonist, it can modulate transcription and potentially influence GPCR gene expression. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $44.00 $66.00 $204.00 $831.00 | 6 | |
A form of vitamin B3 that may affect gene expression via its role in redox reactions and sirtuin modulation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
It is known to modulate several signaling pathways and could have an indirect effect on GPCR gene expression. | ||||||