GPR172A Activators
GPR172A activators are a class of chemical compounds that specifically target and modulate the activity of the G-protein-coupled receptor 172A (GPR172A), which is a protein receptor found in various tissues and organs throughout the human body. GPR172A, also known as TGR5, is a bile acid receptor, and its activation plays a crucial role in mediating various physiological processes related to bile acid metabolism and homeostasis. These activators are designed to interact with GPR172A, leading to the activation of downstream signaling pathways and the subsequent regulation of various biological responses.
The chemical structures of GPR172A activators vary, but they share the common feature of being capable of binding to and activating GPR172A. These compounds are typically small molecules, and their mechanism of action involves binding to the receptor's extracellular domain, which initiates intracellular signaling cascades. The activation of GPR172A by these compounds has been shown to influence various physiological processes, including the regulation of bile acid synthesis and secretion, glucose metabolism, and energy expenditure. Additionally, GPR172A activators have gained attention for their potential role in the gut-brain axis, as they can modulate gastrointestinal motility and secretion, which may have implications for metabolic health and gut-related disorders.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Oleanolic Acid | 508-02-1 | sc-205775 sc-205775A | 100 mg 500 mg | $86.00 $302.00 | 8 | |
Oleanolic acid is a naturally occurring triterpenoid found in various plants. It has been shown to activate GPR172A and is thought to play a role in regulating bile acid metabolism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylate cyclase, which can indirectly activate GPR172A through the cAMP signaling pathway. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
DIM is a compound found in cruciferous vegetables and has been reported to activate GPR172A. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
This natural compound found in the bark of certain trees has been identified as an activator of GPR172A. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in red wine and various fruits, may activate GPR172A indirectly through its effects on cellular signaling pathways. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is a flavonoid found in many fruits and vegetables and has been investigated for its potential to activate GPR172A. | ||||||