GOLT1A Inhibitors
GOLT1A Inhibitors are a set of chemical compounds that impair the functional activity of GOLT1A through various mechanisms affecting the Golgi apparatus and vesicular trafficking. Brefeldin A and Golgicide A target ARF and GBF1, respectively, both of which are key regulators of Golgi structure and function, leading to the inhibition of GOLT1A by collapsing the Golgi structure critical for its vesicle trafficking function. Monensin and Nocodazole,by altering the intra-Golgi pH and disrupting microtubule polymerization, compromise GOLT1A's ability to facilitate proper vesicular transport. The inhibition of dynamin by Dynasore and the disruption of actin filaments by Cytochalasin D also impede GOLT1A's role by blocking vesicle scission and destabilizing the Golgi apparatus structure. Similarly, Tunicamycin and IL-1 beta induce ER stress and the unfolded protein response, which can lead to Golgi dysfunction, thereby indirectly reducing GOLT1A activity. H-89, by inhibiting PKA, may alter protein phosphorylation states that are crucial for maintaining Golgi dynamics, hindering GOLT1A's function in trafficking processes.
Additionally, Bafilomycin A1 indirectly affects GOLT1A activity by disrupting autophagic flux, which is involved in Golgi remodeling; Taxol, by hyperstabilizing microtubules, interferes with the dynamics necessary for GOLT1A-mediated vesicle transport; and Lysophosphatidic Acid, by impacting actin cytoskeleton dynamics, can further impair GOLT1A function within the Golgi complex. Collectively, these inhibitors demonstrate a range of biochemical actions that converge on the impairment of GOLT1A's role in the Golgi apparatus, affecting its capacity to execute vesicular trafficking and impacting various aspects of cellular transport and protein processing. Each inhibitor's mechanism of action diminishes GOLT1A's activity through a unique but interconnected pathway, disrupting the protein's ability to maintain cellular homeostasis and transport functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A disrupts the Golgi apparatus by inhibiting the ADP-ribosylation factor (ARF), a small GTPase involved in vesicle formation. As GOLT1A is a Golgi-localized protein that functions in trafficking, Brefeldin A’s action leads to the inhibition of GOLT1A by disrupting the Golgi structure and function, thus diminishing its trafficking capabilities. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A is a specific inhibitor of the Golgi BFA resistance factor 1 (GBF1), a GEF for ARF1, which is critical for maintaining Golgi structure. Inhibition of GBF1 by Golgicide A results in disruption of Golgi integrity, thereby indirectly diminishing GOLT1A activity related to Golgi-dependent vesicular trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Monensin is an ionophore that alters intra-Golgi pH and cation homeostasis, impairing vesicular transport. Such alteration in the Golgi environment would impair the function of GOLT1A by preventing the proper trafficking of Golgi-processed proteins. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, which is essential for vesicle transport between the Golgi and other cellular compartments. The inhibition of microtubule dynamics indirectly hinders GOLT1A functionality, as it relies on microtubules for Golgi-related transport. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is an inhibitor of dynamin, a GTPase important for the scission of clathrin-coated vesicles. By blocking vesicular scission, Dynasore indirectly inhibits GOLT1A function, as GOLT1A depends on vesicle formation and trafficking for its role in the Golgi apparatus. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D disrupts actin filaments, which are crucial for maintaining Golgi structure and vesicle movement. The perturbation of actin dynamics can indirectly diminish GOLT1A's role in trafficking by destabilizing the Golgi apparatus structure. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation by blocking the transfer of N-acetylglucosamine to dolichol phosphate. This action results in the accumulation of misfolded glycoproteins within the ER, leading to ER stress and the subsequent potential impairment of GOLT1A function in the Golgi as a response to the unfolded protein response. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent inhibitor of Protein Kinase A (PKA). Given that PKA can phosphorylate proteins involved in Golgi organization, H-89 may indirectly diminish GOLT1A activity by altering Golgi dynamics and trafficking. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Bafilomycin A1 is a specific inhibitor of V-ATPase, which disrupts lysosomal acidification and autophagy. By impairing autophagic flux, it could indirectly affect GOLT1A function due to the role of autophagy in Golgi remodeling and vesicle trafficking. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Taxol stabilizes microtubules, preventing their disassembly. This hyperstabilization of microtubules can disrupt normal microtubule dynamics required for Golgi vesicle transport, indirectly affecting GOLT1A function. | ||||||