GOLGA8R Inhibitors
GOLGA8R inhibitors belong to a distinctive class of chemical compounds designed to selectively target and modulate the activity of the Golgin A8-related protein (GOLGA8R). GOLGA8R is a member of the Golgin family, which plays a crucial role in regulating vesicle trafficking and maintaining the structural integrity of the Golgi apparatus within cells. The Golgi apparatus is a vital cellular organelle responsible for the processing and sorting of proteins and lipids. GOLGA8R, specifically, is implicated in the tethering of vesicles to the Golgi membrane, facilitating the proper transportation and secretion of cellular cargo.
Chemical compounds categorized as GOLGA8R inhibitors are meticulously designed to interfere with the normal function of GOLGA8R, often through competitive binding or allosteric modulation. By inhibiting GOLGA8R, these compounds aim to disrupt the intricate processes of vesicle trafficking and Golgi organization, potentially leading to downstream effects on cellular homeostasis. Researchers and pharmaceutical developers are keenly interested in exploring the physiological consequences of GOLGA8R inhibition, with a focus on unraveling the intricate molecular mechanisms underlying intracellular transport. The development of GOLGA8R inhibitors represents a promising avenue for gaining insights into cellular dynamics and may open new avenues for understanding fundamental aspects of cell biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent phosphoinositide 3-kinase (PI3K) inhibitor. By inhibiting PI3K, wortmannin disrupts the PI3K/AKT signaling pathway, which can indirectly lead to decreased trafficking of vesicles from the Golgi apparatus, where GOLGA8R is localized, thus affecting GOLGA8R's function in vesicle formation and transport. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Brefeldin A is an inhibitor of ADP-ribosylation factor (ARF), a small GTPase involved in vesicle formation at the Golgi complex. By inhibiting ARF, Brefeldin A disrupts the normal functioning of the Golgi apparatus, potentially reducing the functional activity of GOLGA8R involved in maintaining Golgi structure. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a GTPase inhibitor that specifically targets dynamin, a protein important for vesicle scission from the Golgi membrane. Inhibition of dynamin can indirectly affect GOLGA8R by disrupting vesicle trafficking and Golgi dynamics where GOLGA8R is functionally significant. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Golgicide A is a selective inhibitor of the cis-Golgi ADP-ribosylation factor 1 (ARF1) GTPase. By targeting ARF1, it disassembles the Golgi structure and would potentially disrupt the function of GOLGA8R by affecting Golgi apparatus integrity. | ||||||
Exo1 | 461681-88-9 | sc-200752 sc-200752A | 10 mg 50 mg | $84.00 $297.00 | 4 | |
Exo1 is an exocyst complex inhibitor which interferes with the exocyst complex involved in tethering vesicles to the plasma membrane. As such, it could impede the vesicular transport processes in which GOLGA8R is implicated, hence indirectly inhibiting its function. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective inhibitor of Cdc42, a small GTPase involved in actin filament organization. Inhibition of Cdc42 could affect cytoskeletal organization and thereby influence the trafficking of vesicles within the Golgi, indirectly affecting GOLGA8R function. | ||||||
SecinH3 | 853625-60-2 | sc-203260 | 5 mg | $278.00 | 6 | |
SecinH3 inhibits cytohesins, which are ARF GTPase exchange factors, leading to the disruption of ARF-mediated trafficking. This could indirectly decrease GOLGA8R activity by affecting Golgi function and vesicle formation. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
SMIFH2 is an inhibitor of the formin family of actin nucleators. Since GOLGA8R is involved in Golgi apparatus function, disrupting actin polymerization can impact Golgi structure and function, thus indirectly affecting GOLGA8R activity. | ||||||
Griseofulvin | 126-07-8 | sc-202171A sc-202171 sc-202171B | 5 mg 25 mg 100 mg | $85.00 $220.00 $598.00 | 4 | |
Griseofulvin interferes with microtubule function. Given that GOLGA8R is implicated in the Golgi apparatus and microtubule dynamics, disrupting microtubules could indirectly decrease GOLGA8R functionality in maintaining Golgi structure. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole is a microtubule-depolymerizing agent. By depolymerizing microtubules, it affects vesicle trafficking and the structural integrity of the Golgi, which would indirectly inhibit GOLGA8R function. | ||||||