GOLGA7B Inhibitors
Inhibitors of GOLGA7B function through a variety of mechanisms that disrupt the protein's normal activity in the Golgi apparatus. Some inhibitors target the membrane trafficking pathways by altering the lipid composition critical for vesicle formation and trafficking, which is central to the functional role of GOLGA7B. For example, the disruption of phospholipase C activity leads to a decrease in vesicular transport that GOLGA7B may facilitate. Other compounds such as those that inhibit dynamin, a GTPase essential for vesicle scission, prevent the proper release of vesicles, thereby indirectly affecting GOLGA7B's role. Furthermore, inhibitors that affect the Golgi apparatus structure, inhibit Golgi-related ARF, and alter Golgi pH and ion gradients can also lead to a functional decrease in GOLGA7B activity. Disruption of microtubule dynamics, either through stabilization or depolymerization, can hinder vesicle transport processes, subsequently reducing GOLGA7B function.
In addition to targeting vesicle trafficking, certain inhibitors interfere with the actin cytoskeleton and microtubule network, both of which are integral to GOLGA7B's role in maintaining Golgi apparatus structure and function. For instance some inhibitors disrupt actin polymerization, which could compromise the integrity of the Golgi apparatus and vesicle movement, thereby inhibiting GOLGA7B. Moreover inhibition of glycosylation processes affects protein folding and transport between the ER and the Golgi, which can indirectly impact GOLGA7B's involvement in these pathways. Similarly binding to phosphoinositides can impair various Golgi-associated signaling pathways, potentially leading to a decrease in GOLGA7B activity.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A potent kinase inhibitor that by inhibiting multiple kinases which are upstream of GOLGA7B, reduces the phosphorylation levels on various proteins, thereby affecting GOLGA7B's role in the modification and sorting of Golgi apparatus proteins. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
Disrupts the structure and function of the Golgi apparatus by inhibiting ADP-ribosylation factor (ARF), which is essential for vesicle formation in the Golgi, indirectly leading to the inhibition of GOLGA7B function in Golgi maintenance. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Interferes with microtubule polymerization, which can indirectly lead to a decrease in GOLGA7B-mediated Golgi organization and trafficking due to the microtubule's role in Golgi structural integrity. | ||||||
Golgicide A | 1005036-73-6 | sc-215103 sc-215103A | 5 mg 25 mg | $191.00 $683.00 | 11 | |
Specifically targets the Golgi brefeldin A resistant guanine nucleotide exchange factor 1 (GBF1), thereby disrupting Golgi structure and function which indirectly affects the role of GOLGA7B in the Golgi apparatus. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Inhibits N-linked glycosylation, affecting protein folding and assembly in the endoplasmic reticulum (ER), indirectly leading to the functional inhibition of GOLGA7B by disrupting the protein processing in the Golgi apparatus. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $155.00 $525.00 | ||
Ionophore that disrupts Golgi function by altering pH and cation homeostasis, indirectly inhibiting GOLGA7B function related to protein trafficking and Golgi apparatus maintenance. | ||||||
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $138.00 $251.00 $631.00 $815.00 $1832.00 | 6 | |
Inhibits Golgi alpha-mannosidase II, disrupting the glycosylation process and thus indirectly inhibiting the function of GOLGA7B in protein modification. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $184.00 $632.00 | 10 | |
An indolizidine alkaloid that inhibits glucosidase I and II in the ER, leading to misfolded glycoproteins that indirectly disrupt GOLGA7B function in glycoprotein processing. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Binds to tubulin, preventing microtubule polymerization, which can indirectly disrupt GOLGA7B's role in maintaining Golgi structure and function due to the reliance of the Golgi on the microtubule network. | ||||||
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Disrupts cellular cholesterol homeostasis, which can indirectly affect GOLGA7B's role in vesicle formation and trafficking, as lipid composition is critical for Golgi function. | ||||||