GMCL1L Activators
Germ cell-less homolog 1-like Activators encompass a diverse array of chemical compounds that induce activation of the protein through various cellular signaling pathways. For instance, Forskolin and Dibutyryl-cAMP enhance cAMP levels within cells, which activate protein kinase A (PKA). PKA then phosphorylates specific targets that can interact with germ cell-less homolog 1-like, leading to its functional activation. Similarly, IBMX prevents the degradation of cAMP, resulting in sustained PKA activity and indirect activation of germ cell-less homolog 1-like through the same cAMP-dependent pathway. Phorbol 12-myristate 13-acetate (PMA) directly stimulates protein kinase C (PKC), another kinase that phosphorylates a broad range of proteins. PKC-mediated phosphorylation events may intersect with germ cell-less homolog 1-like pathways, enhancing its activity.
Additional molecules, such as Ionomycin and Calmodulin Inhibitors, manipulate intracellular calcium levels, thereby influencing calcium-dependent kinases that can modulate the phosphorylation state of proteins associated with germ cell-less homolog 1-like. This modulation can lead to the activation of germ cell-less homolog 1-like. Okadaic Acid, by inhibiting protein phosphatases that counteract kinase activity, leads to a net increase in protein phosphorylation, which could promote the activation of germ cell-less homolog 1-like.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP enhances PKA activity, which can phosphorylate proteins that interact with germ cell-less homolog 1-like, leading to its activation. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
IBMX is a non-specific inhibitor of phosphodiesterases, which prevents cAMP degradation, thereby indirectly enhancing the activity of PKA and potentially leading to the activation of germ cell-less homolog 1-like. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A, leading to increased phosphorylation levels of proteins, which could enhance the activity of germ cell-less homolog 1-like by stabilizing its associated complexes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates that may interact with germ cell-less homolog 1-like, leading to its activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, activating calcium-dependent protein kinases and possibly enhancing the activity of germ cell-less homolog 1-like through phosphorylation pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that activates stress-activated protein kinases (SAPKs), which can phosphorylate a range of substrates that could interact with germ cell-less homolog 1-like, leading to its activation. | ||||||
W-7 | 61714-27-0 | sc-201501 sc-201501A sc-201501B | 50 mg 100 mg 1 g | $163.00 $300.00 $1642.00 | 18 | |
W-7 inhibits calmodulin, which can disrupt downstream calcium-signaling processes, potentially leading to compensatory mechanisms that activate germ cell-less homolog 1-like. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA, which can then phosphorylate interaction partners of germ cell-less homolog 1-like, enhancing its activity. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a non-specific kinase inhibitor, but at low doses, it can act selectively on certain kinases, potentially leading to altered phosphorylation states that activate germ cell-less homolog 1-like. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to compensatory activation of other signaling pathways, potentially resulting in the phosphorylation and activation of proteins associated with germ cell-less homolog 1-like. | ||||||