Gm694 Activators
Steroid receptor associated and regulated protein (SRARP) activators encompass a range of chemical compounds that interact with various steroid hormone receptors. These interactions are crucial for the activation and regulation of genes involved in diverse biological processes. The chemicals presented here are natural ligands or analogs that, once bound to their respective receptors, lead to conformational changes in these receptors, allowing them to interact with co-regulatory proteins such as SRARP. This interaction is a critical component in the recruitment of transcriptional machinery, ultimately enhancing the functional activity of SRARP within the target gene promoters it regulates.
The functional mechanisms of SRARP activators are directly linked to the transcriptional regulatory roles of steroid receptors. When ligands such as estradiol, testosterone, dihydrotestosterone (DHT), cortisol, and aldosterone bind to their cognate receptors, these receptors undergo a transformation that enables their binding to specific DNA sequences known as hormone response elements. This, in turn, facilitates the transcription of nearby genes. SRARP, being associated with these receptors, is posited to be a pivotal factor in this transcriptional regulation, likely influencing the expression of genes in a manner that supports cellular functions ranging from metabolism to growth and immune responses. Similarly, compounds like 1,25-Dihydroxyvitamin D3, retinoic acid, thyroxine (T4), triiodothyronine (T3), lithocholic acid, and hydroxycholesterols interact with their respective receptors to enhance the functional activity of SRARP by influencing gene expression related to calcium metabolism, cell differentiation, metabolic rate, bile acid metabolism, and cholesterol homeostasis, respectively.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $63.00 $182.00 | 8 | |
Estradiol binds to and activates estrogen receptors, which can interact with SRARP due to its association with steroid receptors. Upon binding, the complex translocates to the nucleus and influences gene transcription, likely affecting SRARP's regulatory roles. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Cortisol binds glucocorticoid receptors, which may involve SRARP in the regulation of metabolic and stress response genes. This interaction enhances SRARP's functional activity in these pathways. | ||||||
Aldosterone | 52-39-1 | sc-210774 sc-210774A sc-210774B sc-210774C sc-210774D sc-210774E | 2 mg 5 mg 10 mg 50 mg 100 mg 250 mg | $259.00 $213.00 $317.00 $1550.00 $3074.00 $7637.00 | 1 | |
Aldosterone binds mineralocorticoid receptors, potentially involving SRARP in the regulation of electrolyte and water balance genes. The binding can activate SRARP's function in these pathways. | ||||||
Progesterone | 57-83-0 | sc-296138A sc-296138 sc-296138B | 1 g 5 g 50 g | $20.00 $52.00 $298.00 | 3 | |
Progesterone activates progesterone receptors, which might involve SRARP in the regulation of reproductive system-related genes. This would enhance SRARP's functional activity in reproductive processes. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
The active form of vitamin D binds to vitamin D receptors, which could involve SRARP in the regulation of calcium metabolism genes. This activation enhances the functional activity of SRARP in these processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid binds to retinoic acid receptors, which could interact with SRARP in the regulation of cell differentiation and proliferation genes. This interaction enhances the functional role of SRARP in these pathways. | ||||||
L-Thyroxine, free acid | 51-48-9 | sc-207813 sc-207813A | 100 mg 500 mg | $35.00 $74.00 | 2 | |
Thyroxine interacts with thyroid hormone receptors, which may involve SRARP in the regulation of metabolic and growth-related genes. This interaction enhances SRARP's functional activity in metabolism and development. | ||||||
L-3,3′,5-Triiodothyronine, free acid | 6893-02-3 | sc-204035 sc-204035A sc-204035B | 10 mg 100 mg 250 mg | $41.00 $77.00 $153.00 | ||
T3 is a more potent form of thyroid hormone that binds to thyroid hormone receptors with high affinity, potentially involving SRARP in the regulation of genes related to metabolism and development. Enhancement of SRARP's activity in these pathways would be expected. | ||||||
Lithocholic acid | 434-13-9 | sc-215262 sc-215262A | 10 g 25 g | $100.00 $272.00 | 1 | |
Lithocholic acid is a secondary bile acid that can activate nuclear receptors like the farnesoid X receptor (FXR), which may involve SRARP in the regulation of genes involved in bile acid metabolism. This would enhance the functional activity of SRARP in these pathways. | ||||||
25-Hydroxycholesterol | 2140-46-7 | sc-214091B sc-214091 sc-214091A sc-214091C | 5 mg 10 mg 25 mg 100 mg | $53.00 $91.00 $169.00 $474.00 | 8 | |
Hydroxycholesterols can act as ligands for liver X receptors (LXRs), which may involve SRARP in the regulation of genes associated with cholesterol homeostasis and metabolism. This interaction enhances SRARP's functional activity in cholesterol metabolism. | ||||||