Date published: 2025-12-7

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GlyT1 Inhibitors

Santa Cruz Biotechnology now offers a broad range of GlyT1 Inhibitors for use in various applications. GlyT1 inhibitors are a specialized class of chemical compounds that target the glycine transporter type 1 (GlyT1), a protein responsible for regulating glycine levels in the synaptic cleft by facilitating its reuptake into presynaptic neurons and glial cells. This regulation is crucial for controlling the inhibitory neurotransmission in the central nervous system, as glycine acts as an essential co-agonist with glutamate at the NMDA (N-methyl-D-aspartate) receptors, which play a significant role in synaptic plasticity, learning, and memory. In scientific research, GlyT1 inhibitors have become vital tools for investigating the molecular mechanisms underlying neurotransmission and neuroplasticity. They provide insights into the role of glycine in modulating neural circuits and have been instrumental in studies exploring synaptic function, neurodevelopment, and neural network behavior. Furthermore, these inhibitors are extensively used in the characterization of GlyT1's structural and functional properties, aiding in the development of novel strategies for modulating neurotransmitter systems. Researchers utilize GlyT1 inhibitors to dissect the intricate dynamics of synaptic signaling and to explore their potential in various experimental models. View detailed information on our available GlyT1 Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

NFPS

405225-21-0sc-204126
sc-204126A
10 mg
50 mg
$195.00
$849.00
(0)

NFPS, as a GlyT1 inhibitor, exhibits distinctive molecular interactions characterized by its ability to form stable complexes with glycine transporters. Its unique structural configuration promotes specific binding affinities, influencing transport kinetics and substrate selectivity. The compound's hydrophobic regions enhance membrane permeability, while its polar functionalities facilitate solvation in aqueous environments, allowing for nuanced modulation of glycine uptake pathways.

ALX 5407 hydrochloride

200006-08-2sc-361102
sc-361102A
10 mg
50 mg
$220.00
$900.00
(0)

ALX 5407 hydrochloride, a GlyT1 inhibitor, showcases unique molecular interactions through its selective binding to glycine transporters. Its structural design enables it to engage in specific hydrogen bonding and hydrophobic interactions, which modulate transporter conformation and activity. The compound's dynamic reaction kinetics allow for rapid equilibrium with target sites, while its solubility characteristics enhance its distribution in biological systems, influencing glycine transport regulation.

Sarcosine hydrochloride

637-96-7sc-264296
sc-264296A
10 g
100 g
$50.00
$280.00
(0)

Sarcosine hydrochloride acts as a GlyT1 modulator, exhibiting distinctive interactions with glycine transporters. Its molecular structure facilitates specific electrostatic and van der Waals forces, promoting conformational changes in the transporter. The compound's affinity for the binding site is influenced by its ionic nature, enhancing its solubility in aqueous environments. This solubility plays a crucial role in its diffusion and interaction dynamics within cellular membranes, impacting glycine uptake mechanisms.

Sarcosine

107-97-1sc-204262
sc-204262A
sc-204262B
sc-204262C
sc-204262D
sc-204262E
25 g
100 g
250 g
1 kg
2.5 kg
5 kg
$45.00
$106.00
$150.00
$565.00
$819.00
$1450.00
(0)

Sarcosine functions as a GlyT1 inhibitor, showcasing unique binding characteristics that alter transporter kinetics. Its structural conformation allows for selective interactions with the glycine transporter, leading to modulation of substrate affinity. The presence of functional groups enhances its ability to form hydrogen bonds, influencing the stability of the glycine-GlyT1 complex. Additionally, its zwitterionic nature contributes to its reactivity and solubility, facilitating effective cellular transport processes.

LY 2365109 hydrochloride

868265-28-5sc-204063
sc-204063A
10 mg
50 mg
$214.00
$825.00
(0)

LY 2365109 hydrochloride acts as a GlyT1 modulator, exhibiting distinctive molecular interactions that influence transporter dynamics. Its specific stereochemistry enables targeted binding to the glycine transporter, affecting the transporter's conformational states. The compound's unique electronic properties facilitate charge distribution, enhancing its affinity for the binding site. Furthermore, its solubility profile supports efficient diffusion across cellular membranes, impacting overall transport efficacy.