Glut10 Inhibitors
Glut10 inhibitors belong to a chemical class characterized by their ability to specifically target and modulate the activity of the Glucose Transporter 10 (Glut10) protein. Glut10 is a member of the facilitative glucose transporter family, which plays a crucial role in the transport of glucose across cell membranes. The inhibitors within this class are designed to bind to Glut10 and interfere with its function, thereby affecting the uptake and distribution of glucose in the body. These inhibitors are typically small organic molecules with specific structural features that enable them to interact selectively with Glut10. By binding to the protein, they can alter its conformation or inhibit its transport activity, ultimately leading to a disruption in glucose transport across the membrane. This targeted inhibition of Glut10 can have significant implications for various biological processes in which glucose uptake is essential, such as cellular metabolism and energy homeostasis.
The development of Glut10 inhibitors requires a deep understanding of the protein's structure and function, as well as the chemical properties and structure-activity relationships of potential inhibitor candidates. Through rational design and optimization, researchers aim to create compounds with high potency and selectivity for Glut10, minimizing off-target effects and maximizing their impact on glucose transport. Glut10 inhibitors hold promise as valuable tools for studying the physiological roles of Glut10 and exploring its involvement in different cellular processes. Additionally, they may find applications in basic research to investigate glucose metabolism and its connection to various diseases. By selectively inhibiting Glut10, these compounds could shed light on the complex interplay between glucose transport, cellular metabolism, and disease states. Their precise mechanism of action and potential effects on glucose uptake make them intriguing candidates for further exploration and evaluation in diverse scientific contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wiskostatin | 253449-04-6 | sc-204399 sc-204399A sc-204399B sc-204399C | 1 mg 5 mg 25 mg 50 mg | $49.00 $124.00 $441.00 $828.00 | 4 | |
WZB117 is a small molecule compound that has shown inhibitory effects on glucose uptake by GLUT1 and GLUT10 in various cancer cell lines. It acts by disrupting the interaction between glucose transporters and heat shock protein 90 (HSP90). | ||||||
STF 31 | 724741-75-7 | sc-364692 | 10 mg | $187.00 | 3 | |
STF-31 is another compound that inhibits glucose uptake by GLUT1 and GLUTIt functions by targeting glucose metabolism and causing metabolic stress in cancer cells. | ||||||
CB 839 | 1439399-58-2 | sc-507354 | 10 mg | $140.00 | ||
CB-839 is a glutaminase inhibitor that indirectly affects SLC2A10 function. By blocking glutaminase, an enzyme involved in glutamine metabolism, CB-839 leads to altered glucose metabolism and decreased glucose uptake in cancer cells. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is a natural flavonoid compound found in various fruits and vegetables. It has been reported to inhibit glucose uptake via GLUT1 and GLUT10 in cancer cells. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone found in soybeans and other legumes. It has been shown to inhibit glucose uptake by GLUT1 and GLUT10, leading to altered glucose metabolism in cancer cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin present in green tea. It has been reported to inhibit glucose uptake mediated by GLUT1 and GLUT10 in cancer cells. | ||||||
Phloretin | 60-82-2 | sc-3548 sc-3548A | 200 mg 1 g | $64.00 $255.00 | 13 | |
Phloretin is a natural compound found in various fruits, including apples. It has been studied as an inhibitor of glucose uptake via GLUT1 and GLUT10. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a polyphenol compound found in grapes and red wine. It has been reported to inhibit glucose uptake mediated by GLUT1 and GLUT10 in cancer cells. | ||||||
Diosgenin | 512-04-9 | sc-205652 sc-205652B sc-205652A | 5 g 25 g 100 g | $47.00 $131.00 $517.00 | 4 | |
Diosgenin is a steroidal saponin found in various plants, including wild yam. It has been investigated for its inhibitory effects on glucose uptake through GLUT1 and GLUT10. | ||||||
Fasentin | 392721-37-8 | sc-215012 sc-215012A | 5 mg 25 mg | $128.00 $449.00 | ||
Fasentin is a small molecule inhibitor that has shown inhibitory effects on glucose uptake via GLUT1 and GLUT10 in cancer cells. | ||||||