Date published: 2025-12-9

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General Crosslinkers

Santa Cruz Biotechnology now offers a broad range of crosslinkers for use in various applications. Crosslinkers are versatile chemical agents that can form covalent bonds between different molecules, thus linking them together. These compounds are crucial in scientific research for stabilizing the structure of proteins, nucleic acids, and other biomolecules, allowing for more accurate studies of their functions and interactions. By creating crosslinked networks, researchers can investigate the three-dimensional structure of macromolecules, study the dynamics of complex biological systems, and enhance the durability and functionality of biomaterials. In material science, crosslinkers are used to develop polymers with improved mechanical properties, such as increased strength and resistance to solvents and heat. Additionally, they play a vital role in developing and optimizing new materials, adhesives, coatings, and composites. The ability of crosslinkers to create strong, stable bonds has also been utilized in various biochemical techniques, such as immunoprecipitation, chromatography, and mass spectrometry, where they help in isolating and identifying specific molecules from complex mixtures. Santa Cruz Biotechnology provides a wide selection of crosslinkers, each with unique properties tailored for specific research needs, ensuring researchers have the tools necessary for their studies. View detailed information on our available crosslinkers by clicking on the product name.

Items 21 to 30 of 344 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

N-Hydroxysulfosuccinimide sodium salt

106627-54-7sc-212220
500 mg
$190.00
1
(1)

N-Hydroxysulfosuccinimide sodium salt serves as an effective crosslinker due to its ability to form stable amide bonds through nucleophilic attack on activated carboxylic groups. Its sulfonate group enhances solubility in polar solvents, promoting efficient reaction kinetics. The compound's unique reactivity profile allows for selective modification of biomolecules, facilitating tailored interactions in polymer networks. Additionally, its low toxicity and high stability make it suitable for diverse applications in materials development.

4-Hydroxybenzyl alcohol

623-05-2sc-238868
10 g
$46.00
1
(0)

4-Hydroxybenzyl alcohol acts as an effective crosslinker, primarily through its phenolic hydroxyl group, which can engage in hydrogen bonding and covalent interactions. This compound promotes the formation of robust networks in polymer systems, enhancing mechanical strength and thermal stability. Its unique reactivity allows for tailored crosslinking pathways, influencing the kinetics of polymerization and the final material properties, such as elasticity and durability.

3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester)

57757-57-0sc-266859
500 mg
$228.00
(1)

3,3'-Dithiodipropionic acid di(N-hydroxysuccinimide ester) serves as a versatile crosslinker, characterized by its ability to form stable covalent bonds through its reactive ester groups. The presence of disulfide linkages facilitates unique redox chemistry, enabling dynamic crosslinking under specific conditions. Its bifunctional nature allows for selective conjugation to biomolecules, enhancing the formation of complex networks. This compound's reactivity is influenced by steric factors, which can modulate the kinetics of crosslinking reactions, making it a valuable tool in material science and bioconjugation applications.

tert-Butyl 4-hydroxybutyrate

59854-12-5sc-258207
500 mg
$267.00
(0)

tert-Butyl 4-hydroxybutyrate serves as a versatile crosslinker, characterized by its ability to engage in hydrogen bonding and esterification reactions. The tert-butyl group enhances steric hindrance, promoting selective interactions within polymer networks. Its hydroxyl functionality allows for dynamic crosslinking, facilitating the formation of robust three-dimensional structures. This compound's unique reactivity and physical properties contribute to improved mechanical strength and thermal stability in composite materials.

3,3′-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester

81069-02-5sc-206694
100 mg
$296.00
(0)

3,3'-Dithiobispropionic Acid Bis-sulfosuccinimidyl Ester serves as a versatile crosslinker, characterized by its ability to form stable amide bonds with primary amines. The presence of sulfosuccinimidyl groups enhances its reactivity, facilitating rapid conjugation in aqueous environments. This compound exhibits a unique bifunctional nature, allowing for the simultaneous linking of multiple biomolecules, which can lead to the formation of complex networks. Its hydrophilic properties ensure compatibility with various biological systems, promoting effective crosslinking without significant steric hindrance.

MTSEA Biotin

162758-04-5sc-221960
10 mg
$209.00
(1)

MTSEA Biotin serves as a versatile crosslinker, characterized by its ability to form covalent bonds with thiol groups in proteins. This reactivity enables the stabilization of protein complexes and facilitates the study of protein-protein interactions. Its biotin moiety allows for easy detection and isolation through avidin or streptavidin binding, enhancing the specificity of assays. The compound's unique structure promotes efficient conjugation, making it a powerful tool in biochemical research.

4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid

175281-76-2sc-238751
1 g
$332.00
(1)

4-[4-(1-Hydroxyethyl)-2-methoxy-5-nitrophenoxy]butyric acid serves as an effective crosslinker, distinguished by its ability to form robust covalent bonds through its reactive carboxylic acid group. The presence of the nitro and methoxy substituents enhances electron delocalization, influencing reaction kinetics and promoting selective interactions with polymer chains. This compound's unique structure facilitates the creation of intricate networks, improving mechanical strength and thermal stability in composite materials.

Glutaraldehyde solution, 50% w/w

111-30-8sc-207716
10 ml
$55.00
1
(1)

Glutaraldehyde solution, 50% w/w, serves as a potent crosslinker, facilitating the formation of stable covalent bonds between biomolecules. Its reactivity is attributed to the presence of aldehyde groups, which readily engage in nucleophilic addition reactions with amines and hydroxyls. This leads to the creation of intricate three-dimensional networks, enhancing structural integrity in polymers and biological materials. The solution's low volatility and high solubility in water further optimize its application in diverse chemical environments.

N,N′,N′′-Triacetylchitotriose

38864-21-0sc-222016
sc-222016A
10 mg
50 mg
$265.00
$1022.00
2
(1)

N,N',N''-Triacetylchitotriose serves as an effective crosslinker, exhibiting strong interactions through its multiple acetylated amine groups. This compound facilitates the formation of stable networks by promoting hydrogen bonding and van der Waals forces, enhancing structural integrity in polymer matrices. Its unique chitin-derived structure allows for selective reactivity, enabling tailored modifications in biopolymer applications. The compound's ability to influence gelation kinetics further underscores its versatility in material science.

(Boc-aminooxy)acetic Acid

42989-85-5sc-212986
1 g
$70.00
(0)

(Boc-aminooxy)acetic Acid functions as an effective crosslinker, distinguished by its aminooxy group that promotes oxime bond formation with aldehydes and ketones. This compound exhibits a unique reactivity that allows for selective interactions with carbonyl-containing molecules, enhancing the precision of crosslinking in various environments. Its Boc protecting group ensures stability and ease of handling, while facilitating controlled deprotection, enabling tailored modifications in diverse chemical contexts.