Date published: 2026-3-21

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General Crosslinkers

Santa Cruz Biotechnology now offers a broad range of crosslinkers for use in various applications. Crosslinkers are versatile chemical agents that can form covalent bonds between different molecules, thus linking them together. These compounds are crucial in scientific research for stabilizing the structure of proteins, nucleic acids, and other biomolecules, allowing for more accurate studies of their functions and interactions. By creating crosslinked networks, researchers can investigate the three-dimensional structure of macromolecules, study the dynamics of complex biological systems, and enhance the durability and functionality of biomaterials. In material science, crosslinkers are used to develop polymers with improved mechanical properties, such as increased strength and resistance to solvents and heat. Additionally, they play a vital role in developing and optimizing new materials, adhesives, coatings, and composites. The ability of crosslinkers to create strong, stable bonds has also been utilized in various biochemical techniques, such as immunoprecipitation, chromatography, and mass spectrometry, where they help in isolating and identifying specific molecules from complex mixtures. Santa Cruz Biotechnology provides a wide selection of crosslinkers, each with unique properties tailored for specific research needs, ensuring researchers have the tools necessary for their studies. View detailed information on our available crosslinkers by clicking on the product name.

Items 161 to 170 of 344 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate

sc-219226
10 mg
$300.00
(0)

N-Succinimidyl 6-(3-Maleimidopropionamido) Hexanoate is a specialized crosslinker featuring a reactive succinimidyl group that enables robust amine coupling. The maleimide component facilitates specific thiol interactions, allowing for precise crosslinking in complex systems. Its hexanoate chain provides a balance of rigidity and flexibility, enhancing molecular mobility. This unique structure promotes efficient reaction kinetics and stability, making it suitable for diverse applications in material science and bioconjugation.

Nonaoxanonacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester

sc-219394
5 mg
$430.00
(0)

Nonaoxanonacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester functions as a versatile crosslinker, characterized by its long hydrophobic chain that enhances solubility in organic solvents. Its dual N-hydroxysuccinimide groups facilitate efficient coupling with amines, leading to robust covalent bonds. The compound exhibits unique reactivity profiles, allowing for controlled crosslinking kinetics and the formation of diverse polymer networks, making it suitable for various applications in material science.

Octaoxahexacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester

sc-219459
5 mg
$430.00
(0)

Octaoxahexacosanedioic Acid Bis(N-Hydroxysuccinimide) Ester functions as a versatile crosslinker, characterized by its long-chain structure that facilitates hydrophobic interactions and enhances solubility in various media. The presence of N-hydroxysuccinimide moieties allows for rapid and selective coupling with amine-containing substrates, promoting efficient crosslinking. Its unique reactivity profile enables the formation of stable networks, influencing the mechanical and thermal properties of the resulting materials.

S-(2-Glycylamidoethyl)dithio-2-pyridine

sc-220008
10 mg
$320.00
(0)

S-(2-Glycylamidoethyl)dithio-2-pyridine serves as a versatile crosslinker, characterized by its ability to engage in selective thiol-disulfide exchange mechanisms. This compound features a unique pyridine moiety that enhances electron delocalization, promoting rapid reaction kinetics. Its amidoethyl groups facilitate strong interactions with various functional groups, allowing for tailored crosslinking in complex matrices. The resulting networks exhibit improved mechanical stability and resilience, making it suitable for diverse applications.

Biotinylamidoethyl]-dithiomethylenemalonic Acid Bis(3-aminopropionic Acid)

sc-221364
5 mg
$430.00
(0)

Biotinylamidoethyl-dithiomethylenemalonic Acid Bis(3-aminopropionic Acid) acts as a versatile crosslinker, characterized by its ability to engage in robust covalent bonding through dithiomethylene moieties. This compound exhibits a high degree of reactivity, allowing for rapid crosslinking under mild conditions. Its unique architecture supports the formation of complex polymeric networks, enhancing stability and resilience while enabling tailored interactions with various substrates.

[Biotinylamidoethyl]-dithiomethylenemalonic Acid Bis(4-aminobutyric Acid)

1322625-02-4sc-221365
5 mg
$300.00
(0)

[Biotinylamidoethyl]-dithiomethylenemalonic Acid Bis(4-aminobutyric Acid) functions as a sophisticated crosslinker, characterized by its dithiomethylene moiety that enables robust thiol-based interactions. This compound exhibits a unique ability to form stable, covalent linkages through its multiple amine-reactive sites, facilitating the creation of complex polymeric structures. Its distinctive reactivity profile allows for tailored assembly in diverse biochemical contexts, enhancing structural integrity and functional versatility.

4-(N-Boc-aminoxyacetamido)benzyl Ethylenediaminetetraacetic Acid, Tetra(t-butyl) Ester

sc-223599
5 mg
$330.00
(0)

4-(N-Boc-aminoxyacetamido)benzyl Ethylenediaminetetraacetic Acid, Tetra(t-butyl) Ester serves as an effective crosslinker, exhibiting remarkable reactivity due to its multiple functional groups. The presence of the Boc-protected amino group enhances nucleophilicity, facilitating robust covalent bonding with various substrates. Its sterically bulky t-butyl esters contribute to solubility and stability, while enabling controlled release of active sites, promoting tailored crosslinking pathways in polymer networks.

2-{N2-[Nα-Benzoylbenzoicamido-N6-6-biotinamidocaproyl]lysinylamido}ethyl-2′-(N-sulfosuccinimidylcarboxy)ethyl Disulfide Sodium Salt

sc-229868
1 mg
$290.00
1
(0)

2-{N2-[Nα-Benzoylbenzoicamido-N6-6-biotinamidocaproyl]lysinylamido}ethyl-2'-(N-sulfosuccinimidylcarboxy)ethyl Disulfide Sodium Salt serves as a versatile crosslinker, featuring a disulfide bond that facilitates reversible covalent interactions. Its sulfosuccinimidyl group enhances reactivity with amines, promoting efficient conjugation. This compound's unique design allows for the formation of stable networks, enabling intricate molecular architectures and dynamic assembly in various biochemical environments.

1,5-Pentanediyl Bismethanethiosulfonate

56-00-8sc-208802
25 mg
$360.00
(0)

1,5-Pentanediyl Bismethanethiosulfonate functions as an effective crosslinker, distinguished by its ability to form covalent bonds through thiosulfonate moieties. This compound exhibits unique reactivity patterns, facilitating rapid crosslinking via nucleophilic attack and subsequent thiol exchange reactions. Its linear structure promotes uniform distribution within polymer matrices, enhancing mechanical strength and thermal stability. The compound's reactivity is further influenced by solvent polarity, allowing for customizable network characteristics.

2-Benzoylpyridine

91-02-1sc-237918
25 g
$20.00
1
(0)

2-Benzoylpyridine serves as an effective crosslinker, exhibiting unique reactivity due to its carbonyl and pyridine functionalities. The electron-rich nitrogen in the pyridine ring enhances its ability to form stable adducts with electrophiles, facilitating diverse crosslinking pathways. Its planar structure allows for π-π stacking interactions, which can influence the kinetics of polymerization. Additionally, the compound's solubility in organic solvents can modulate reaction rates and product formation, making it versatile in various applications.