GBP3 Activators

GBP3 plays a crucial role in cellular responses to inflammation and infection, and is responsive to oxidative stress and other types of cellular stress signals. It is also involved in processes such as autophagy, cell survival, and cell differentiation. Chemicals such as L-Buthionine sulfoximine (BSO) and Deferoxamine (DFO) can enhance the activation of GBP3, as they lead to increased intracellular reactive oxygen species and the induction of hypoxia-inducible factor 1-alpha respectively, both of which are signals that GBP3 responds to. Tunicamycin and Thapsigargin induceendoplasmic reticulum stress, leading to the unfolded protein response, another stress signal that GBP3 is responsive to. In addition, 2-Deoxy-D-glucose inhibits glycolysis, leading to cellular stress that can enhance GBP3 activation.

On the other hand, Bafilomycin A1 and Rapamycin enhance GBP3's functional activity by inducing autophagy, a process in which GBP3 is involved. Dexamethasone, Tamoxifen, and Retinoic acid can activate different receptors and transcription factors, leading to the upregulation of genes involved in cell survival and inflammation, processes that GBP3 is involved in. Finally, MG-132 and Staurosporine induce cellular stress by inhibiting the proteasome and protein kinases respectively, leading to apoptosis and cellular stress signals that enhance GBP3 activation.