Gastrokine 1 Activators
Chemical activators of Gastrokine 1 employ various cellular pathways to modulate the protein's activity through phosphorylation, a process where a phosphate group is added to a protein, often resulting in an alteration of its function. Phorbol 12-myristate 13-acetate (PMA) activates Protein Kinase C (PKC), which is involved in a wide variety of cellular processes, and this kinase can directly phosphorylate Gastrokine 1, thereby modulating its role in gastric mucosal defense. Similarly, Forskolin raises the levels of intracellular cAMP, which in turn activates Protein Kinase A (PKA). PKA is another kinase that can phosphorylate Gastrokine 1, influencing its activity within the cell. Ionomycin, by increasing intracellular calcium levels, activates calmodulin-dependent protein kinases, which can also target Gastrokine 1 for phosphorylation. Okadaic Acid, by inhibiting protein phosphatases, ensures that proteins like Gastrokine 1 remain phosphorylated for longer periods, potentially affecting its activity state.
In addition to these, Anisomycin activates stress-activated protein kinases which can target Gastrokine 1 during cellular stress responses. The PI3K inhibitor LY294002 can indirectly lead to the activation of kinases that may phosphorylate Gastrokine 1, while Rapamycin inhibits mTOR and may activate upstream kinases that target Gastrokine 1. The activation of cyclin-dependent kinases by 6-Benzylaminopurine could also result in the phosphorylation of Gastrokine 1, possibly influencing cell cycle regulation. Thapsigargin, by disrupting calcium homeostasis, might lead to the activation of kinases that phosphorylate Gastrokine 1. Dibutyryl-cAMP, a stable cAMP analog, activates PKA, which is known to phosphorylate and thus affect the activity of Gastrokine 1. Phosphatidic Acid can activate the mTOR signaling pathway, potentially leading to the phosphorylation of Gastrokine 1. Lastly, Calyculin A, by inhibiting protein phosphatases, can cause a sustained phosphorylated state of Gastrokine 1, influencing its function in the cell.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates Protein Kinase C (PKC), which is known to phosphorylate proteins leading to their activation. Since Gastrokine 1 is involved in gastric mucosal defense, PKC-mediated phosphorylation could lead to its functional activation as part of the mucosal protection response. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin raises intracellular cAMP levels, which activate Protein Kinase A (PKA). PKA can phosphorylate target proteins, potentially including Gastrokine 1, to regulate their activity as part of cellular signaling processes. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, which can activate calmodulin-dependent protein kinases. These kinases could phosphorylate and activate Gastrokine 1, contributing to its role in gastric protection. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid inhibits protein phosphatases, which leads to increased phosphorylation levels within the cell. This in turn could maintain Gastrokine 1 in a phosphorylated and active state, as it is presumed to be regulated by phosphorylation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin activates stress-activated protein kinases, which can lead to the phosphorylation of various cellular proteins. Gastrokine 1 could be activated through this mechanism as part of the cellular stress response. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can lead to the activation of alternative pathways compensating for PI3K inhibition. This could result in the activation of kinases that phosphorylate and activate Gastrokine 1. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR, which may lead to the activation of upstream kinases that could phosphorylate Gastrokine 1, thus activating it in response to altered nutrient signaling. | ||||||
6-Benzylaminopurine | 1214-39-7 | sc-202428 sc-202428A | 1 g 5 g | $20.00 $51.00 | ||
6-Benzylaminopurine is known to activate cyclin-dependent kinases, which may phosphorylate Gastrokine 1 as part of cell cycle regulation, potentially activating it. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis, leading to the activation of several signaling pathways. This disruption could activate kinases that phosphorylate and activate Gastrokine 1. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a stable cAMP analog that activates PKA. PKA in turn can phosphorylate and activate Gastrokine 1 as part of the cAMP-dependent signaling pathways. | ||||||