Date published: 2026-5-19

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γGCS Inhibitors

Santa Cruz Biotechnology now offers a broad range of γGCS Inhibitors for use in various applications. γGCS Inhibitors target gamma-glutamylcysteine synthetase (γGCS), the rate-limiting enzyme in the synthesis of glutathione, which is a crucial antioxidant that protects cells from oxidative damage and maintains cellular redox balance. Inhibiting γGCS allows researchers to study the regulatory mechanisms of glutathione biosynthesis and its impact on cellular processes such as detoxification, apoptosis, and cell proliferation. By studying the effects of γGCS inhibition, researchers can gain insights into the role of glutathione in maintaining cellular homeostasis and its involvement in the cellular response to environmental challenges. These inhibitors also play a key role in high-throughput screening assays designed to identify new modulators of γGCS activity, facilitating the discovery of novel regulatory pathways and potential research targets. The application of γGCS Inhibitors supports the development of experimental models that dissect the complex interactions between glutathione and other cellular components, thereby enhancing our understanding of cellular regulation and adaptation to oxidative stress. By enabling precise manipulation of glutathione synthesis, these inhibitors allow for comprehensive studies of the enzyme's function in cellular physiology. View detailed information on our available γGCS Inhibitors by clicking on the product name.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

L-Methionine [R,S]-Sulfoximine

15985-39-4sc-207806
1 g
$396.00
(0)

L-Methionine [R,S]-Sulfoximine functions as a potent inhibitor of gamma-glutamylcysteine synthetase (γ-GCS), a key enzyme in glutathione biosynthesis. Its unique sulfoximine group facilitates strong interactions with the enzyme's active site, leading to a conformational change that impedes substrate binding. This compound exhibits distinct kinetic properties, resulting in a competitive inhibition profile that alters cellular redox states and influences metabolic pathways related to oxidative stress.