Date published: 2025-12-18

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γGCS Antibodies

Santa Cruz Biotechnology features a diverse variety of γGCS monoclonal antibodies for investigating gamma-glutamylcysteine synthetase function. γGCS Antibodies are validated for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Gamma-glutamylcysteine synthetase is a critical enzyme in the synthesis of glutathione, a vital antioxidant that protects cells from oxidative stress. By regulating intracellular levels of glutathione, γGCS plays a significant role in cellular defense mechanisms and is implicated in various diseases, including cancer and neurodegenerative disorders. Understanding the function and regulation of γGCS is essential for developing therapeutic strategies targeting oxidative stress-related conditions. Research into γGCS expression patterns and activity levels can reveal important insights about cellular responses to oxidative stress. Investigating γGCS regulation mechanisms may uncover new therapeutic targets for treating diseases associated with oxidative damage. Studies of γGCS activity provide valuable information about glutathione metabolism and antioxidant defense systems. Santa Cruz Biotechnology monoclonal antibodies enable researchers worldwide to advance scientific understanding of γGCS and its role in human health and disease.

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γGCS Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

γ-GCSc Antibody (H-5)

sc-390811mouse IgG2a κ338-637 (h)WB, IP, IF, IHC(P), ELISAm, r, h
38
(9)

γ-GCSc Antibody (D-4)

sc-166382mouse IgG1 κ338-637 (h)WB, IP, IF, ELISAm, r, h
8
(3)

γ-GCSc Antibody (F-9)

sc-166356mouse IgG2a κ338-637 (h)WB, IP, IF, IHC(P), ELISAm, r, h
5
(4)

γ-GCSc Antibody (G-12)

sc-166345mouse IgG1 κ338-637 (h)WB, IP, IF, ELISAm, r, h
2
(4)

γ-GCSm Antibody (E-4)

sc-55586mouse IgG2aFL (h)WB, IP, IF, IHC(P), ELISAm, r, h
44
(15)

γ-GCSm Antibody (F-8)

sc-166603mouse IgG2b κFL (h)WB, IP, IF, ELISAm, r, h
5
(3)

γ-GCSm Antibody (G-4)

sc-55585mouse IgG2b1-274 (h)WB, IP, IF, IHC(P), ELISAm, r, h
3
(5)

γGCS CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

γ-GCSc CRISPR/Cas9 KO Plasmid (h2)

sc-401133-KO-2hGene KnockoutGFP0
(0)

γ-GCSc HDR Plasmid (h2)

sc-401133-HDR-2hHomology Directed RepairPuromycin0
(0)

γ-GCSc Double Nickase Plasmid (h)

sc-401133-NIChGene KnockoutPuromycin0
(0)

γ-GCSc Double Nickase Plasmid (h2)

sc-401133-NIC-2hGene KnockoutPuromycin0
(0)

γ-GCSc CRISPR/Cas9 KO Plasmid (m)

sc-420573mGene KnockoutGFP0
(0)

γ-GCSc HDR Plasmid (m)

sc-420573-HDRmHomology Directed RepairPuromycin0
(0)

γ-GCSc Double Nickase Plasmid (m)

sc-420573-NICmGene KnockoutPuromycin0
(0)

γ-GCSc Double Nickase Plasmid (m2)

sc-420573-NIC-2mGene KnockoutPuromycin0
(0)

γ-GCSm CRISPR/Cas9 KO Plasmid (h)

sc-418078hGene KnockoutGFP0
(0)

γ-GCSm HDR Plasmid (h)

sc-418078-HDRhHomology Directed RepairPuromycin0
(0)

γ-GCSm Double Nickase Plasmid (h)

sc-418078-NIChGene KnockoutPuromycin0
(0)

γ-GCSm Double Nickase Plasmid (h2)

sc-418078-NIC-2hGene KnockoutPuromycin0
(0)

γ-GCSm CRISPR/Cas9 KO Plasmid (m)

sc-420574mGene KnockoutGFP0
(0)

γ-GCSm HDR Plasmid (m)

sc-420574-HDRmHomology Directed RepairPuromycin0
(0)

γ-GCSm Double Nickase Plasmid (m)

sc-420574-NICmGene KnockoutPuromycin0
(0)

γ-GCSm Double Nickase Plasmid (m2)

sc-420574-NIC-2mGene KnockoutPuromycin0
(0)

γGCS CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

γ-GCSc CRISPR Activation Plasmid (h)

sc-401133-ACThGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSc CRISPR Activation Plasmid (h2)

sc-401133-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSc Lentiviral Activation Particles (h)

sc-401133-LAChGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSc Lentiviral Activation Particles (h2)

sc-401133-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSc CRISPR Activation Plasmid (m)

sc-420573-ACTmGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSc CRISPR Activation Plasmid (m2)

sc-420573-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSc Lentiviral Activation Particles (m)

sc-420573-LACmGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSc Lentiviral Activation Particles (m2)

sc-420573-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm CRISPR Activation Plasmid (h)

sc-418078-ACThGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm CRISPR Activation Plasmid (h2)

sc-418078-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm Lentiviral Activation Particles (h)

sc-418078-LAChGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm Lentiviral Activation Particles (h2)

sc-418078-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm CRISPR Activation Plasmid (m)

sc-420574-ACTmGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm CRISPR Activation Plasmid (m2)

sc-420574-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm Lentiviral Activation Particles (m)

sc-420574-LACmGene ActivationPuro, Blast, Hygro0
(0)

γ-GCSm Lentiviral Activation Particles (m2)

sc-420574-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

γGCS siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

γ-GCSc siRNA (h)

sc-41978hGene SilencingN/A
4
(0)

γ-GCSc shRNA Plasmid (h)

sc-41978-SHhGene SilencingPuromycin
4
(0)

γ-GCSc shRNA (h) Lentiviral Particles

sc-41978-VhGene SilencingPuromycin
4
(0)

γ-GCSc siRNA (m)

sc-41979mGene SilencingN/A
3
(0)

γ-GCSm siRNA (h)

sc-40602hGene SilencingN/A0
(0)

γ-GCSm shRNA Plasmid (h)

sc-40602-SHhGene SilencingPuromycin0
(0)

γ-GCSm shRNA (h) Lentiviral Particles

sc-40602-VhGene SilencingPuromycin0
(0)

γ-GCSm siRNA (m)

sc-40603mGene SilencingN/A0
(0)

γ-GCSm shRNA Plasmid (m)

sc-40603-SHmGene SilencingPuromycin0
(0)

γ-GCSm shRNA (m) Lentiviral Particles

sc-40603-VmGene SilencingPuromycin0
(0)

GSH1 shRNA Plasmid (m)

sc-41979-SHmGene SilencingPuromycin
3
(0)

GSH1 shRNA (m) Lentiviral Particles

sc-41979-VmGene SilencingPuromycin
3
(0)