GABA T-3 Activators
GABA T-3 Activators, comprising a range of compounds and ions, play integral roles in enhancing the functionality of GABA T-3, a transporter encoded by the SLC6A11 gene, responsible for the reuptake of GABA, the primary inhibitory neurotransmitter in the brain. GABA itself is the primary substrate for GABA T-3, and its presence is essential for the transporter's activity in regulating neurotransmitter levels. Essential ions such as Sodium Chloride, Chloride Ions, Magnesium Chloride, and Potassium Chloride contribute to the transporter's functionality. Sodium and Chloride ions are crucial for maintaining the electrochemical gradient that drives GABA's active transport, while Magnesium and Potassium help stabilize neuronal membranes and maintain ionic balance.
In addition to these ions, the activity of GABA T-3 is modulated by various compounds that interact with GABAergic signaling. Taurine, Zinc sulfate solution, and Guanosine Diphosphate (GDP) influence GABA receptor function and G-protein mediated signaling pathways, indirectly affecting the reuptake dynamics of GABA T-3. (+)-Bicuculline, by acting as a GABA receptor antagonist, increases the availability of GABA in the synaptic cleft, potentially enhancing the substrate availability for GABA T-3. Conversely, Muscimol and (±)-Baclofen, as GABA receptor agonists, modulate GABAergic neurotransmission, which can indirectly influence GABA reuptake by GABA T-3. Lastly, Vigabatrin, by inhibiting GABA transaminase, leads to increased GABA levels, thereby providing more substrate for GABA T-3 mediated reuptake. Collectively, these GABA T-3 Activators underscore the complex interplay of biochemical and ionic factors that enhance the role of GABA T-3 in neurotransmitter regulation, highlighting its critical function in maintaining neural excitatory/inhibitory balance.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
GABA | 56-12-2 | sc-203053 sc-203053A sc-203053B sc-203053C | 10 g 25 g 5 kg 10 kg | $64.00 $136.00 $459.00 $765.00 | 2 | |
GABA can enhance GABA T-3 activity by serving as its primary substrate. GABA T-3, encoded by the SLC6A11 gene, is a transporter responsible for the reuptake of GABA from the synaptic cleft. The presence of GABA is crucial for GABA T-3's function in regulating neurotransmitter levels. | ||||||
Sodium Chloride | 7647-14-5 | sc-203274 sc-203274A sc-203274B sc-203274C | 500 g 2 kg 5 kg 10 kg | $19.00 $30.00 $60.00 $110.00 | 15 | |
Sodium Chloride can enhance GABA T-3 activity by maintaining the electrochemical gradient necessary for the transporter's function. Sodium ions are essential for the active transport of GABA across cell membranes by GABA T-3. | ||||||
Taurine | 107-35-7 | sc-202354 sc-202354A | 25 g 500 g | $48.00 $102.00 | 1 | |
Taurine can enhance GABA T-3 activity by modulating GABAergic signaling and potentially affecting the reuptake of GABA. Taurine has been shown to interact with GABA receptors and may influence GABA T-3's function in GABA reuptake. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc sulfate solution can enhance GABA T-3 activity by acting as a modulator at GABAergic synapses. Zinc ions are known to influence GABA receptor function and may also affect the activity of GABA transporters like GABA T-3. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium Chloride can enhance GABA T-3 activity by stabilizing neuronal membranes and affecting neurotransmitter transport. Magnesium ions can impact the function of neurotransmitter transporters, including GABA T-3. | ||||||
Potassium Chloride | 7447-40-7 | sc-203207 sc-203207A sc-203207B sc-203207C | 500 g 2 kg 5 kg 10 kg | $55.00 $155.00 $285.00 $455.00 | 5 | |
Potassium Chloride can enhance GABA T-3 activity by maintaining the overall ionic balance crucial for the transporter's function. Potassium ions play a role in the electrochemical gradients necessary for neurotransmitter transport. | ||||||
Guanosine 5′-diphosphate sodium salt hydrate (GDP) | 146-91-8 non-salt | sc-507402 | 10 mg | $645.00 | ||
GDP can enhance GABA T-3 activity by influencing the G-protein mediated signaling pathways that regulate neurotransmitter transporters. G-protein signaling can modulate the function of transporters like GABA T-3. | ||||||
(+)-Bicuculline | 485-49-4 | sc-202498 sc-202498A | 50 mg 250 mg | $82.00 $281.00 | ||
Bicuculline, a GABA receptor antagonist, can indirectly enhance GABA T-3 activity by increasing the availability of GABA in the synaptic cleft, potentially increasing the substrate availability for GABA T-3. | ||||||
Muscimol | 2763-96-4 | sc-200460 sc-200460A | 5 mg 25 mg | $161.00 $537.00 | 2 | |
Muscimol, a GABA receptor agonist, can indirectly enhance GABA T-3 activity by modulating GABAergic signaling, potentially affecting GABA reuptake dynamics. | ||||||
(±)-Baclofen | 1134-47-0 | sc-200464 sc-200464A | 1 g 5 g | $56.00 $258.00 | ||
(±)-Baclofen, a GABA-B receptor agonist, can indirectly enhance GABA T-3 activity by affecting GABAergic neurotransmission, potentially influencing GABA reuptake by GABA T-3. | ||||||