Gβ 5 Inhibitors
The chemical class of Gβ5 inhibitors presents a versatile array of compounds designed to modulate G protein signaling pathways either directly or indirectly, underscoring the intricate nature of Gβ5 regulation and its involvement in various cellular functions. Among the direct inhibitors, M119 and its analogue, Gallein, along with Pertussis Toxin, disrupt Gβγ interactions, effectively inhibiting downstream signaling pathways reliant on Gβγ. This direct interference provides researchers with specific tools to investigate the role of Gβ5 in diverse physiological processes. On the indirect modulation front, Neomycin, the M119 analogue, and LY294002 offer alternative strategies by interfering with Gβγ interactions, potentially influencing cellular processes associated with Gβ5. These compounds, while not directly targeting Gβ5 itself, impact its function by disrupting critical protein-protein interactions within the G protein signaling cascade. This nuanced approach allows for a more comprehensive exploration of the multifaceted roles played by Gβ5 in cellular signaling.
The landscape of Gβ5 inhibition further expands with compounds like Methyl-β-cyclodextrin, Suramin, DIDS, Dynasore, Thapsigargin, and CCG-50014, each offering indirect inhibition through distinct mechanisms. Methyl-β-cyclodextrin affects lipid raft organization, influencing the localization of G proteins within the cell membrane. Suramin and DIDS interfere with ion channels and transporters, potentially altering the cellular environment and affecting Gβ5-related processes. Dynasore disrupts intracellular calcium homeostasis, contributing to the overall modulation of G protein signaling pathways. CCG-50014, on the other hand, inhibits G protein signaling through alternative mechanisms, adding another layer of complexity to the toolkit of Gβ5 inhibitors. The diverse modes of action displayed by these compounds highlight the complexity of Gβ5 regulation and its involvement in various cellular functions. Gβ5 plays a crucial role in cellular processes ranging from signal transduction to ion channel regulation, and its dysregulation has been implicated in a variety of pathological conditions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Gallein | 2103-64-2 | sc-202631 | 50 mg | $85.00 | 20 | |
Gallein is a small molecule that disrupts Gβγ interactions, inhibiting G protein signaling pathways. By interfering with the Gβγ complex, Gallein potentially influences processes regulated by Gβ 5 , shedding light on the specific roles of Gβ 5 in various cellular contexts. Further exploration of Gallein's effects on Gβ 5 -related signaling pathways can contribute to a deeper understanding of the intricate regulation of G protein signaling and its implications for cellular function. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Methyl-β-cyclodextrin disrupts lipid raft organization, affecting G protein signaling. As Gβ 5 localization is influenced by lipid rafts, this compound indirectly modulates Gβ 5 function. By altering membrane microdomains, Methyl-β-cyclodextrin can impact cellular processes associated with Gβ 5 , providing insights into the intricate regulation of G protein signaling and its potential implications for various physiological functions. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $451.00 | 3 | |
Pertussis Toxin disrupts G protein signaling by ADP-ribosylation of Gαi, preventing Gβγ association. This inhibits downstream signaling pathways dependent on Gβγ, indirectly modulating processes associated with Gβ 5 . | ||||||
Suramin sodium | 129-46-4 | sc-507209 sc-507209F sc-507209A sc-507209B sc-507209C sc-507209D sc-507209E | 50 mg 100 mg 250 mg 1 g 10 g 25 g 50 g | $152.00 $214.00 $728.00 $2601.00 $10965.00 $21838.00 $41096.00 | 5 | |
Suramin is a polyanionic compound that interferes with G protein signaling by inhibiting Gαβγ interactions. By disrupting the Gβγ complex, Suramin indirectly influences cellular processes associated with Gβ 5 . | ||||||
Neomycin sulfate | 1405-10-3 | sc-3573 sc-3573A | 1 g 5 g | $27.00 $35.00 | 20 | |
Neomycin disrupts G protein signaling by interfering with Gβγ interactions. By preventing Gβγ association, Neomycin indirectly modulates cellular processes associated with Gβ 5 . The compound's impact on Gβ 5 -related signaling pathways offers insights into the specific roles of Gβ 5 in various physiological contexts. Further exploration is needed to delineate the consequences of Neomycin on Gβ 5 function and contribute to our understanding of G protein signaling regulation. | ||||||
DIDS, Disodium Salt | 67483-13-0 | sc-203919A sc-203919B sc-203919 sc-203919C | 25 mg 100 mg 250 mg 1 g | $51.00 $163.00 $286.00 $683.00 | 6 | |
DIDS (4,4'-Diisothiocyano-2,2'-stilbenedisulfonic acid) is an inhibitor of anion channels and transporters, and it may indirectly modulate G protein signaling pathways. As Gβ 5 is involved in certain signaling cascades, the impact of DIDS on ion channels and transporters could influence cellular processes associated with Gβ 5 . | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor that may indirectly modulate G protein signaling pathways. As Gβ 5 is implicated in various signaling cascades, interference with PI3K by LY294002 could influence cellular processes associated with Gβ 5 . The specific consequences of LY294002 on Gβ 5 -related signaling pathways warrant further investigation to elucidate the intricate regulation of G protein signaling and its potential implications for cellular function. | ||||||
Dynamin Inhibitor I, Dynasore | 304448-55-3 | sc-202592 | 10 mg | $89.00 | 44 | |
Dynasore is a dynamin inhibitor that may indirectly modulate G protein signaling pathways. As Gβ 5 is involved in certain signaling cascades, interference with dynamin by Dynasore could influence cellular processes associated with Gβ 5 . The specific consequences of Dynasore on Gβ 5 -related signaling pathways necessitate further investigation to delineate the intricate regulation of G protein signaling and its implications for cellular function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin inhibits the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) pump, potentially influencing G protein signaling pathways. As Gβ 5 is implicated in certain signaling cascades, disruption of intracellular calcium homeostasis by Thapsigargin could impact cellular processes associated with Gβ 5 . | ||||||