Gβ 2 Inhibitors
Gβ2 inhibitors belong to a specific class of chemical compounds that target the G protein beta subunit 2 (Gβ2). G proteins are a vital component of cell signaling pathways, facilitating communication between cell surface receptors and intracellular effectors. Gβ2, a subunit of the G protein heterotrimer, plays a crucial role in modulating various cellular processes, including signal transduction, gene expression, and cytoskeletal rearrangements. Gβ2 is primarily found in neural tissues, where it participates in the transmission of signals in response to various extracellular cues. The Gβ2 inhibitors are designed to interact with Gβ2 and modulate its activity. These inhibitors are characterized by their specific binding to the Gβ2 subunit, thereby disrupting its interactions with other signaling components within the cell. By doing so, Gβ2 inhibitors can potentially influence downstream signaling cascades, altering cellular responses to a range of stimuli. The mechanism of action of Gβ2 inhibitors involves interfering with the association between Gβ2 and other signaling partners, thereby regulating pathways that are crucial for proper cellular function.
The development of Gβ2 inhibitors holds promise for shedding light on the intricate mechanisms underlying cellular signaling processes and their modulation. These inhibitors serve as valuable tools for researchers to investigate the functions of Gβ2 and the broader G protein signaling pathways. Through the inhibition of Gβ2, these compounds can help unravel the complex interplay of molecules that contribute to various physiological and cellular responses. In-depth understanding of Gβ2 inhibitors' effects could offer insights into potential avenues for manipulating cellular signaling events for various purposes, contributing to the advancement of scientific knowledge in the realm of cell biology and molecular signaling.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Propranolol | 525-66-6 | sc-507425 | 100 mg | $180.00 | ||
Propranolol is a non-selective β-adrenergic receptor inhibitor. It competitively blocks β2 adrenergic receptors on smooth muscle cells, leading to decreased cAMP production and vasodilation. This results in decreased heart rate and reduced contractility. | ||||||
Nadolol | 42200-33-9 | sc-253175 | 1 g | $184.00 | ||
Nadolol is a non-selective β-adrenergic receptor inhibitor. It binds to β2 adrenergic receptors, inhibiting their activation by epinephrine and norepinephrine. This leads to reduced heart rate, contractility, and bronchodilation, making it useful in conditions like hypertension and angina. | ||||||
Pindolol | 13523-86-9 | sc-204847 sc-204847A | 100 mg 1 g | $194.00 $760.00 | ||
Pindolol is a non-selective β-adrenergic receptor inhibitor. It acts as a partial agonist, meaning it can bind to β2 receptors and activate them to a lesser extent than full agonists. This results in reduced sympathetic activity and is used in conditions like hypertension and angina. | ||||||
Sotalol hydrochloride | 959-24-0 | sc-203699 sc-203699A | 10 mg 50 mg | $68.00 $251.00 | 3 | |
Sotalol is a non-selective β-adrenergic receptor inhibitor with Class III antiarrhythmic properties. It also blocks potassium channels, prolonging action potentials. | ||||||
Timolol maleate | 26921-17-5 | sc-507468 | 100 mg | $500.00 | ||
Timolol is a non-selective β-adrenergic receptor inhibitor. By blocking β2 receptors, it decreases aqueous humor production. It also lowers heart rate and blood pressure, used for hypertension and as an anti-migraine prophylactic. | ||||||
Alprenolol | 13655-52-2 | sc-507469 | 50 mg | $130.00 | ||
Alprenolol is a non-selective β-adrenergic receptor inhibitor. It competitively blocks β2 receptors, resulting in reduced heart rate, contractility, and vasodilation. It was one of the earliest beta blockers used to manage conditions like hypertension and angina. | ||||||
Labetalol | 36894-69-6 | sc-484723 | 50 mg | $180.00 | ||
Labetalol is a non-selective β-adrenergic receptor inhibitor with alpha-blocking activity. It lowers blood pressure by blocking both β2 receptors and alpha-1 receptors, leading to vasodilation and reduced cardiac output. | ||||||
Bucindolol | 71119-11-4 | sc-203860 sc-203860A | 10 mg 50 mg | $250.00 $785.00 | 2 | |
Bucindolol is a non-selective β-adrenergic receptor inhibitor with additional alpha-1 blocking activity. It also exhibits intrinsic sympathomimetic activity and membrane-stabilizing effects. | ||||||
Carvedilol | 72956-09-3 | sc-200157 sc-200157A sc-200157B sc-200157C sc-200157D | 100 mg 1 g 10 g 25 g 100 g | $124.00 $240.00 $530.00 $999.00 $1530.00 | 2 | |
Carvedilol is a non-selective β-adrenergic receptor inhibitor with alpha-1 blocking and antioxidant properties. It reduces heart rate, vasodilates, and reduces oxidative stress. It's used in heart failure, hypertension, and post-myocardial infarction. | ||||||
Metoprolol Tartrate | 56392-17-7 | sc-205751 sc-205751A | 5 g 25 g | $107.00 $243.00 | 3 | |
Metoprolol is a selective β1-adrenergic receptor inhibitor. By blocking β1 receptors, it reduces heart rate and contractility, making it useful in conditions like hypertension, angina, and heart failure. It has less effect on bronchial smooth muscle compared to non-selective blockers. | ||||||