Sotalol hydrochloride CAS: 959-24-0
MF: C12H20N2O3S•HCl
MW: 308.82
A potent β adrenergic antagonist.

Sotalol hydrochloride (CAS 959-24-0)

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Application Sotalol hydrochloride is a potent β adrenergic antagonist
CAS 등록번호: 959-24-0
순도: ≥99%
분자량: 308.82
분자식: C12H20N2O3S•HCl
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).

Sotalol hydrochloride is a compound categorized with class III antiarrhythmic activity with a mechanism of action that prolongs the action potential and refraction of cardiac tissue through non-selective yet potent β-adronergic blocking activity. Sotalol hydrochloride is also considered a non-selective β blocker and a potassium channel blocker with an IC50 of 43 µM.


References

1. Zanetti, L.A. 1993. Clin Pharm. 12: 883-891. PMID: 8137605
2. Claudel, J.P. and Touboul, P. 1995. Pacing Clin Electrophysiol. 18: 451-467. PMID: 7770366
3. Bauman, J.L. 1997. Pharmacotherapy. 17: 76S-83S; discussion 89S. PMID: 9085343

Physical State :
Solid
용해도 :
Soluble in phosphate buffered saline (100 mM), DMSO (62 mg/ml at 25° C), ethanol (<1 mg/ml at 25° C), water (62 mg/ml at 25° C), and methanol.
저장 :
Store at room temperature
녹는점 :
206.5-207° C
비등점 :
443.3° C at 760
굴절률 :
n20D 1.57 (Predicted)
IC50 :
Adrenergic receptor β: IC50 = 7.2 µM (human); Potassium channel : IC50 = 43 µM
Ki 데이타 :
Beta adrenoceptor: Ki= 0.93 µM
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
WGK Germany :
3
RTECS :
PB0826000
PubChem CID :
Merck Index :
14: 8728
MDL Number :
MFCD00242937
EC Number :
213-496-0
SMILES :
CC(C)NCC(C1=CC=C(C=C1)NS(=O)(=O)C)O.Cl

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인용 1 to 1 of 1 합계

PMID: # 31629310  J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 121793.

인용 1 to 1 of 1 합계
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