frizzled-5 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
XAV-939 is a tankyrase inhibitor that disrupts the Wnt/β-catenin signaling pathway by stabilizing Axin and promoting the degradation of β-catenin, thereby inhibiting frizzled-5 signaling and downstream gene expression involved in cell proliferation and differentiation. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
IWP-2 is a small molecule inhibitor of Wnt production that blocks the secretion of Wnt ligands, preventing their binding to frizzled-5 receptors and inhibiting downstream Wnt signaling pathways, ultimately leading to the suppression of cellular processes regulated by frizzled-5, such as cell growth and differentiation. | ||||||
LGK 974 | 1243244-14-5 | sc-489380 sc-489380A | 5 mg 50 mg | $352.00 $1270.00 | 2 | |
LGK-974 is a potent inhibitor of porcupine, an enzyme involved in the acylation of Wnt proteins. By blocking Wnt palmitoylation, LGK-974 disrupts Wnt ligand secretion and frizzled-5 activation, leading to the inhibition of Wnt signaling pathways and downstream cellular processes associated with frizzled-5 activity. | ||||||
Wnt-C59 | 1243243-89-1 | sc-475634 sc-475634A sc-475634B | 5 mg 10 mg 50 mg | $210.00 $320.00 $1250.00 | 1 | |
Wnt-C59 is a selective inhibitor of porcupine that prevents the acylation and secretion of Wnt ligands, thereby inhibiting their binding to frizzled-5 receptors and suppressing downstream Wnt signaling pathways involved in cellular proliferation, migration, and differentiation, ultimately leading to the inhibition of frizzled-5-mediated effects. | ||||||
KY02111 | 1118807-13-8 | sc-397043 sc-397043A | 5 mg 25 mg | $79.00 $336.00 | ||
KY02111 is a potent inhibitor of the canonical Wnt/β-catenin signaling pathway that disrupts the interaction between β-catenin and TCF/LEF transcription factors, inhibiting the transcriptional activation of target genes downstream of frizzled-5, and ultimately suppressing cellular processes regulated by frizzled-5, such as cell proliferation and differentiation. | ||||||
Pyrvinium Pamoate | 3546-41-6 | sc-476920A sc-476920 | 250 mg 500 mg | $224.00 $414.00 | ||
Pyrvinium pamoate inhibits Wnt/β-catenin signaling by promoting the degradation of β-catenin, thus suppressing downstream gene expression regulated by frizzled-5 and inhibiting cellular processes such as cell proliferation and differentiation mediated by frizzled-5 activity. | ||||||
NSC 668036 | 144678-63-7 | sc-507412 | 5 mg | $175.00 | ||
NSC668036 is an inhibitor of Wnt/β-catenin signaling that disrupts the interaction between β-catenin and TCF/LEF transcription factors, leading to the suppression of downstream gene expression regulated by frizzled-5, ultimately inhibiting cellular processes such as cell proliferation and differentiation mediated by frizzled-5 activity. | ||||||
2-((4-Oxo-3-phenyl-3,4,6,7-tetrahydrothieno[3,2-d]pyrimidin-2-yl)thio)-N-(5-phenylpyridin-2-yl)acetamide | 1427782-89-5 | sc-477902 | 10 mg | $330.00 | ||
Also called IWP-L6, this compound is a small molecule inhibitor of Wnt production that blocks the secretion of Wnt ligands, preventing their binding to frizzled-5 receptors and inhibiting downstream Wnt signaling pathways, ultimately leading to the suppression of cellular processes regulated by frizzled-5, such as cell growth and differentiation. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $159.00 $236.00 $398.00 $465.00 | 1 | |
Salinomycin inhibits Wnt/β-catenin signaling by inducing the degradation of β-catenin, thereby suppressing downstream gene expression regulated by frizzled-5 and inhibiting cellular processes such as cell proliferation and differentiation mediated by frizzled-5 activity. | ||||||
PRI-724 | 1422253-38-0 | sc-507535 | 25 mg | $255.00 | ||
PRI-724 is a small molecule inhibitor of the Wnt/β-catenin signaling pathway that disrupts the interaction between β-catenin and CBP, leading to the suppression of downstream gene expression regulated by frizzled-5, ultimately inhibiting cellular processes such as cell proliferation and differentiation mediated by frizzled-5 activity. | ||||||