Date published: 2025-12-15

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Fes Inhibitors

The chemical class of Fes Inhibitors encompasses a diverse group of compounds primarily characterized by their ability to interfere with the signaling pathways related to the Fes protein. These inhibitors are not direct antagonists of Fes but exert their influence by targeting associated or intersecting pathways, thus indirectly modulating Fes activity. The primary mechanism involves the inhibition of tyrosine kinases, which are crucial for the activation of many signaling cascades, including those involving Fes. Many of these compounds, such as Imatinib, Dasatinib, and Nilotinib, are known for their effectiveness in inhibiting BCR-ABL kinase and Src family kinases, which have a significant role in cell growth and differentiation pathways that overlap with Fes signaling. By inhibiting these kinases, these compounds indirectly affect the activity of Fes. Similarly, compounds targeting EGFR, like Erlotinib and Gefitinib, can modulate Fes activity by influencing the epidermal growth factor signaling pathway, which has ties to Fes signaling. The inhibition of VEGFR, PDGFR, and c-Kit by compounds such as Sorafenib and Pazopanib also plays a role in modulating pathways that intersect with Fes signaling.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Herbimycin A

70563-58-5sc-3516
sc-3516A
100 µg
1 mg
$272.00
$1502.00
13
(1)

Herbimycin A is a notable compound characterized by its ability to disrupt protein-protein interactions through specific binding to target kinases. Its unique structural features enable it to modulate signaling pathways, particularly those involved in cell growth and differentiation. The compound exhibits distinct reaction kinetics, influencing the phosphorylation state of various substrates. Additionally, its hydrophobic regions enhance membrane permeability, facilitating cellular uptake and interaction with intracellular targets.

Imatinib

152459-95-5sc-267106
sc-267106A
sc-267106B
10 mg
100 mg
1 g
$25.00
$117.00
$209.00
27
(1)

A tyrosine kinase inhibitor that can interfere with BCR-ABL kinase, which is linked to the same signaling pathways as Fes, potentially inhibiting its activity.

Dasatinib

302962-49-8sc-358114
sc-358114A
25 mg
1 g
$47.00
$145.00
51
(1)

Another tyrosine kinase inhibitor, known to affect Src family kinases, which are connected to Fes signaling, thereby possibly reducing Fes activity.

Erlotinib Hydrochloride

183319-69-9sc-202154
sc-202154A
10 mg
25 mg
$74.00
$119.00
33
(1)

Targets the epidermal growth factor receptor (EGFR), a protein interacting with Fes signaling pathways, potentially diminishing Fes activity.

Sorafenib

284461-73-0sc-220125
sc-220125A
sc-220125B
5 mg
50 mg
500 mg
$56.00
$260.00
$416.00
129
(3)

Inhibits multiple tyrosine kinases, including VEGFR and PDGFR, which are part of pathways overlapping with Fes, possibly leading to reduced Fes signaling.

Sunitinib, Free Base

557795-19-4sc-396319
sc-396319A
500 mg
5 g
$150.00
$920.00
5
(0)

A multi-targeted tyrosine kinase inhibitor, affects pathways shared with Fes, potentially reducing its signaling capacity.

Pazopanib

444731-52-6sc-396318
sc-396318A
25 mg
50 mg
$127.00
$178.00
2
(1)

Inhibits VEGFR, PDGFR, and c-Kit, which are involved in pathways parallel to Fes, potentially leading to diminished Fes activity.

Nilotinib

641571-10-0sc-202245
sc-202245A
10 mg
25 mg
$205.00
$405.00
9
(1)

Primarily targets BCR-ABL, similar to Imatinib, and can indirectly influence Fes signaling through shared pathways.

Gefitinib

184475-35-2sc-202166
sc-202166A
sc-202166B
sc-202166C
100 mg
250 mg
1 g
5 g
$62.00
$112.00
$214.00
$342.00
74
(2)

Targets EGFR, thus affecting pathways that intersect with those regulated by Fes, potentially reducing its activity.

Lapatinib

231277-92-2sc-353658
100 mg
$412.00
32
(1)

Inhibits both EGFR and HER2/neu, affecting signaling pathways that are interconnected with Fes, potentially leading to reduced Fes activity.