FBXO34 Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
An mTOR inhibitor that leads to the suppression of protein synthesis by acting on the mTORC1 complex. FBXO34 is implicated in protein ubiquitination and degradation; the inhibition of protein synthesis can result in reduced substrate availability for FBXO34-mediated ubiquitination. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
A proteasome inhibitor that prevents the degradation of ubiquitinated proteins. By blocking proteasomal activity, it indirectly increases the levels of ubiquitinated proteins, potentially saturating the capacity of FBXO34 to target additional substrates for degradation. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
An autophagy inhibitor that prevents the fusion of autophagosomes with lysosomes, thereby blocking the degradation of autophagocytosed material. This may lead to accumulation of ubiquitinated proteins, indirectly impacting FBXO34s role in protein turnover. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $280.00 | 1 | |
A NEDD8-activating enzyme inhibitor that prevents neddylation of cullin proteins, essential for the function of Cullin-RING ubiquitin ligases (CRLs) which FBXO34 is a part of. This leads to the inactivation of CRLs and subsequently inhibits FBXO34s ubiquitination function. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
A proteasome inhibitor that blocks the degradation of polyubiquitinated proteins, potentially leading to reduced FBXO34 function by increasing competition for substrates or by feedback inhibition due to the accumulation of ubiquitinated proteins. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $134.00 $215.00 $440.00 $496.00 | 19 | |
A selective proteasome inhibitor that irreversibly binds to the proteasome, leading to the accumulation of polyubiquitinated proteins and potentially diminishing the ability of FBXO34 to ubiquitinate new substrates due to substrate competition. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
A protease inhibitor that impedes the breakdown of proteins within lysosomes. An increase in lysosomal protein levels may indirectly affect the turnover of proteins regulated by FBXO34, as the pool of degradable proteins would be altered. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $165.00 $575.00 | 60 | |
A specific inhibitor of the proteasome that causes the accumulation of ubiquitinated proteins in the cell, which could indirectly inhibit the function of FBXO34 by overwhelming the ubiquitin-proteasome system with substrates. | ||||||
Ubiquitin E1 Inhibitor, PYR-41 | 418805-02-4 | sc-358737 | 25 mg | $360.00 | 4 | |
An irreversible inhibitor of ubiquitin-activating enzyme E1, leading to decreased ubiquitin conjugation. This can indirectly inhibit FBXO34 by reducing the ubiquitination of its substrates, as FBXO34 is involved in the targeting of proteins for ubiquitin-mediated degradation. | ||||||