FBXO3 Activators
FBXO3 activators encompass a diverse array of chemical compounds that indirectly enhance the ubiquitin ligase function of FBXO3 by affecting various signaling pathways and stress responses within the cell. Betulinic Acid, through its role in the ubiquitin-proteasome pathway, potentiates the ubiquitin ligase activity of FBXO3, which is crucialSince you have provided the protein name as "FBXO3" and implied that the gene name is "FBXO3".
FBXO3 Activators are comprised of various chemical compounds that indirectly enhance the ubiquitin-proteasome-dependent proteolytic function of FBXO3. Forskolin, through the elevation of cAMP, activates PKA, which can phosphorylate and prime proteins for FBXO3-mediated ubiquitination, thereby augmenting FBXO3's ability to target proteins for degradation. Epigallocatechin gallate modifies the cellular kinase landscape, potentially rendering certain proteins more susceptible to FBXO3's ubiquitination process. LY294002's inhibition of PI3K leads to a decrease in AKT phosphorylation, which in turn can increase the pool of proteins available for FBXO3 to ubiquitinate, thereby amplifying its proteolytic activity. Similarly, MG132 and Bortezomib, by blocking proteasomal degradation, cause an accumulation of ubiquitinated proteins, which might increase the demand for FBXO3's ubiquitination function. PMA's activation of PKC is another route by which FBXO3's activity could be enhanced, as PKC-mediated phosphorylation events may facilitate the recognition of substrates by FBXO3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Betulinic Acid | 472-15-1 | sc-200132 sc-200132A | 25 mg 100 mg | $117.00 $344.00 | 3 | |
Betulinic Acid induces the ubiquitin-proteasome pathway by activating specific E3 ubiquitin ligases. FBXO3, being part of the SCF (SKP1-CUL1-F-box protein) E3 ligase complex, is potentially activated, enhancing its role in protein ubiquitination and subsequent proteasomal degradation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin is known to modulate the NF-κB pathway. By inhibiting the degradation of IκB, curcumin can indirectly increase the functional activity of FBXO3, as FBXO3 targets proteins for ubiquitination within this pathway, thus enhancing NF-κB pathway regulation. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane activates the Nrf2 signaling pathway, which is involved in the response to oxidative stress. FBXO3, through its function in protein ubiquitination, could be implicated in the turnover of Nrf2 or its repressor Keap1, thereby modulating the pathway's activity. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol is a known activator of SIRT1. Activation of SIRT1 can lead to deacetylation of certain substrates, potentially including components of the SCF complex. This may indirectly enhance the activity of FBXO3 by promoting its assembly or stability within the complex. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG132 is a proteasome inhibitor that can lead to the accumulation of ubiquitinated proteins. The accumulation of substrates could indirectly enhance the functional activity of FBXO3 by increasing the demand for its E3 ligase activity. | ||||||
Epoxomicin | 134381-21-8 | sc-201298C sc-201298 sc-201298A sc-201298B | 50 µg 100 µg 250 µg 500 µg | $137.00 $219.00 $449.00 $506.00 | 19 | |
Epoxomicin, similar to MG132, is a selective proteasome inhibitor. It can lead to an upregulation of E3 ubiquitin ligases like FBXO3 to compensate for the impaired degradation and maintain protein homeostasis. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol induces heat shock proteins and can inhibit NF-κB signaling. By modulating the cellular stress response, celastrol may indirectly increase the activity of FBXO3 as part of the cellular attempt to restore homeostasis through protein degradation pathways. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A is known to disrupt proteasomal function. This disruption can result in the upregulation of E3 ligases like FBXO3 to counterbalance the impaired degradation process and regulate protein levels. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $135.00 $1085.00 | 115 | |
Bortezomib is another proteasome inhibitor that can indirectly increase the activity of FBXO3 by causing the accumulation of ubiquitinated proteins, which could enhance the demand for E3 ligase activity. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine increases the levels of reactive oxygen species (ROS) and can induce oxidative stress. This may indirectly enhance the activity of FBXO3 by increasing the need for degradation of damaged proteins through the ubiquitin-proteasome system. | ||||||