FBP Activators
FBP Activators encompass a diverse group of chemical compounds that indirectly enhance the functional activity of FBP by modulating various cellular metabolic pathways. AMPK Activator AICAR and Glucagon Mimetic L-168,049 both work by stimulating pathwaysSince no specific "Protein Name" and "Gene Name" were provided in the "naming instructions", I will use "FBP" as a placeholder for the "Protein Name" in the following narrative description, based on the assumption that FBP refers to Fructose-1,6-bisphosphatase. If a different protein name is intended, please provide it to receive a tailored response.
FBP Activators are a series of chemical entities that serve to augment the activity of FBP through a variety of metabolic and signaling pathways. The activation process begins with compounds like AMPK Activator AICAR and mTOR Inhibitor Rapamycin, which catalyze a metabolic shift by promoting gluconeogenesis over glycolysis, thereby increasing the demand for FBP's catalytic action. Forskolin, PEPCK Inducer, acts by raising cAMP levels, subsequently enhancing PEPCK expression, a precursor step to FBP's action in gluconeogenesis. Similarly, the cAMP Analog 8-Br-cAMP and CREB Activator IBMX elevate intracellular cAMP, thereby activating PKA and CREB, respectively, leading to an upregulation of gluconeogenic enzymes including FBP. The Glucagon Mimetic L-168,049 and the Insulin Antagonist S961 orchestrate an increase in FBP activity by modulating hormonal signals that dictate the rate of glucose production, ensuring that FBP is more actively engaged in its role of converting fructose-1,6-bisphosphate to fructose 6-phosphate.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
AICAR is an activator of AMP-activated protein kinase (AMPK) which, when activated, can inhibit the glycolysis pathway while activating gluconeogenesis. As a result, AICAR increases the functional activity of FBP by shifting cellular energy metabolism towards glucose production. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin elevates cyclic AMP, which in turn stimulates the expression of enzymes in the gluconeogenesis pathway, including PEPCK which is upstream of FBP. By enhancing PEPCK, Forskolin indirectly promotes the role of FBP in gluconeogenesis. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline has been implicated in enhancing G6Pase activity, which is a downstream effect that requires increased gluconeogenesis and subsequent FBP activity to ensure a supply of glucose-6-phosphate. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is known to suppress gluconeogenesis. Inhibition of mTOR therefore indirectly supports the activation of FBP by reducing the inhibition of gluconeogenesis. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Cortisol acts to increase gluconeogenesis and subsequently the activity of FBP, by enhancing the expression of enzymes involved in this pathway. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Br-cAMP) is a cAMP analog that activates PKA, leading to an increased gluconeogenic flux and thereby enhancing the activity of FBP. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
Isobutylmethylxanthine (IBMX) increases intracellular cAMP by inhibiting phosphodiesterases, which activates CREB and upregulates gluconeogenesis, thereby promoting FBP activity. | ||||||
Fenofibrate | 49562-28-9 | sc-204751 | 5 g | $41.00 | 9 | |
Fenofibrate, through its agonistic effect on PPARα, upregulates the expression of genes involved in gluconeogenesis, including those that FBP is a part of, leading to enhanced FBP activity. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $31.00 $53.00 $124.00 $374.00 | 25 | |
By inhibiting acetyl-CoA carboxylase, Soraphen A reduces malonyl-CoA levels, relieving the inhibition of carnitine palmitoyltransferase 1 (CPT1) and enhancing the supply of substrates for gluconeogenesis, which indirectly enhances FBP activity. | ||||||
D-(+)-Biotin | 58-85-5 | sc-204706 sc-204706A sc-204706B | 1 g 5 g 25 g | $41.00 $107.00 $333.00 | 1 | |
Biotin acts as a cofactor for pyruvate carboxylase, an enzyme that provides oxaloacetate for gluconeogenesis, thus supporting the functional activity of FBP downstream. | ||||||