FAT4 Activators
FAT4 Activators are a diverse set of chemical compounds that enhance the functional activity of FAT4 through a variety of signaling pathways and cellular processes. Forskolin, Sphingosine-1-phosphate, and the cell-permeable cAMP analog 8-Bromo-cAMP elevate second messenger levels within the cell, leading to the activation of kinases such as PKA and PKC, which are known to regulate processes such as cell adhesion and polarity, wherein FAT4 is a critical player. Similarly, calcium ionophores like Ionomycin and A23187 raise intracellular calcium, a key regulator of many signaling pathways, thereby indirectly enhancing FAT4's role in cell morphology and adhesion. These compounds, through their specific actions, potentiate FAT4's involvement in maintaining and modifying cell structure and interactions with theextracellular matrix.
Compounds such as LY294002, U0126, SB203580, and Epigallocatechin gallate (EGCG) interact with key enzymes in signaling pathways that indirectly enhance FAT4's cellular functions. SB203580 selectively inhibits MEK and p38 MAPK, respectively, which can lead to an upregulation of FAT4's activity, as these enzymes are involved in pathways that overlap with those regulated by FAT4. EGCG and Genistein, through their inhibition of multiple kinases and tyrosine kinases, may relieve negative regulation on FAT4, thus promoting its role in cell-cell adhesion and communication. The collective action of these activators through modulation of signaling cascades provides a multi-faceted approach to enhancing the function of FAT4, without directly increasing its expression or altering its intrinsic activity.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate and enhance the functional activity of FAT4 by promoting its localization to cell junctions, where it can influence cell polarity and adhesion. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels, activating calcium-dependent signaling pathways. This activation can enhance FAT4 function, as FAT4 is involved in calcium-dependent cell adhesion and morphogenesis processes. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate substrates affecting FAT4 activity. PKC has been implicated in the regulation of cell adhesion and morphology, processes in which FAT4 plays a critical role. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
D-erythro-Sphingosine-1-phosphate binds to its receptors, initiating signaling cascades that influence cytoskeletal arrangement and cell adhesion, thereby potentially enhancing the FAT4-mediated signaling involved in these processes. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a p38 MAPK inhibitor that can modulate cellular stress responses. Inhibition of p38 potentially enhances FAT4 signaling pathways involved in the regulation of cell shape and adhesion. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). The resultant increase in cytosolic calcium levels can enhance FAT4 signaling pathways related to cell-cell adhesion and morphology. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a kinase inhibitor with a broad range of targets. By inhibiting certain kinases, EGCG may reduce competitive signaling and enhance FAT4's role in cell polarity and adhesion signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is a tyrosine kinase inhibitor that by inhibiting competitive tyrosine kinase signaling can lead to the enhancement of FAT4 function in cell adhesion and polarity. | ||||||
8-Bromoadenosine 3′,5′-cyclic monophosphate | 23583-48-4 | sc-217493B sc-217493 sc-217493A sc-217493C sc-217493D | 25 mg 50 mg 100 mg 250 mg 500 mg | $108.00 $169.00 $295.00 $561.00 $835.00 | 2 | |
8-Bromoadenosine 3',5'-cyclic monophosphate (8-Bromo-cAMP) is a cell-permeable cAMP analog that activates PKA. Activation of PKA can enhance FAT4's role in the regulation of cell polarity and adhesion by affecting substrates involved in these processes. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is a calcium ionophore, similar to Ionomycin, and can enhance intracellular calcium levels, thus potentially enhancing FAT4 activity in calcium-dependent pathways involved in cell morphogenesis and adhesion. | ||||||