FARP2 Inhibitors

FARP2 inhibitors target and inhibit the function of FERM, RhoGEF, and pleckstrin domain protein 2 (FARP2). FARP2 is a multifunctional enzyme that plays a crucial role in intracellular signaling pathways, particularly those involving cytoskeletal dynamics and cell morphology. It acts as a guanine nucleotide exchange factor (GEF) for certain members of the Rho family of GTPases, which are key regulators of the actin cytoskeleton. The inhibition of FARP2 by these compounds is significant as it can influence the enzyme's role in actin cytoskeleton reorganization and various cellular processes. The molecular structure of FARP2 inhibitors is characterized by specific features that allow for effective and selective interaction with the enzyme. These inhibitors typically contain functional groups that can bind to the GEF domain of FARP2, thereby inhibiting its catalytic activity.