FAM38B Inhibitors

The class of FAM38B inhibitors, or PIEZO2 inhibitors, would consist of compounds that can alter the function of the PIEZO2 ion channel. Since PIEZO2 is involved in the cellular response to physical forces, these compounds might modulate the channel's ability to open in response to mechanical stimuli. For instance, Ruthenium Red and GsMTx4 are known to non-specifically affect ion channels, including mechanosensitive channels, and could thus modulate PIEZO2. Gadolinium ions and other ions like La3+ are recognized for their ability to block mechanosensitive channels, which includes PIEZO2. Aminoglycosides such as streptomycin could affect PIEZO2 by blocking its pore or altering its gating mechanism. Compounds known to influence intracellular calcium levels, such as BAPTA-AM, SKF-96365, and calcium channel blockers like verapamil and nifedipine, could modify PIEZO2 activity due to the channel's permeability to calcium. These compounds could indirectly affect PIEZO2 function by changing the cellular ionic environment or the signaling pathways that regulate the channel's activity.