FAM130A2 Inhibitors
Chemical inhibitors of FAM130A2 can exert their effects by various mechanisms, each targeting different aspects of cytoskeletal dynamics. Wortmannin and LY294002 are inhibitors of phosphatidylinositol 3-kinase (PI3K), a kinase that participates in signaling pathways essential for actin filament assembly. By inhibiting PI3K, these compounds disrupt downstream signaling, which is crucial for the organization of the actin cytoskeleton, a process where FAM130A2 is involved. Similarly, Cytochalasin D and Latrunculin A target actin filaments directly. Cytochalasin D binds to the barbed ends of actin filaments, blocking their elongation, whereas Latrunculin A binds to actin monomers, preventing them from polymerizing. The proper function of FAM130A2 depends on the dynamic balance of actin assembly and disassembly, and so the action of these chemicals can lead to the inhibition of FAM130A2 by stalling the restructuring of the actin network.
On the microtubule front, Paclitaxel and Nocodazole interfere with microtubule dynamics, albeit in opposite ways. Paclitaxel stabilizes microtubules, preventing their disassembly, which is necessary for the normal functioning of FAM130A2 in maintaining cytoskeletal integrity. On the other hand, Nocodazole inhibits microtubule polymerization, resulting in a similar functional impairment of FAM130A2, which relies on an intact microtubule network. Colchicine also binds to tubulin, the building block of microtubules, and inhibits its polymerization, further contributing to the disruption of microtubule-dependent processes that FAM130A2 might be involved in. The inhibition of myosin II ATPase activity by Blebbistatin and myosin light chain kinase (MLCK) by ML-7 affects myosin function, which is pivotal for maintaining cytoskeletal structure and facilitating cell motility, processes where FAM130A2 plays a role. Lastly, Y-27632, an inhibitor of Rho-associated protein kinase (ROCK), disrupts actin cytoskeleton organization and cell adhesion, leading to the inhibition of FAM130A2 by disturbing the signaling pathways it is involved in. CK-636 targets the actin cytoskeleton by inhibiting the Arp2/3 complex and formin-mediated actin assembly, respectively, which are essential for the polymerization and branching of actin filaments that FAM130A2 might regulate.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K), a kinase involved in various signaling pathways, including those that regulate cytoskeletal rearrangement and cell migration. Inhibition of PI3K by Wortmannin would impair these processes, potentially leading to the functional inhibition of FAM130A2, which is implicated in cytoskeletal organization. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is another specific inhibitor of PI3K. By inhibiting PI3K, LY294002 can disrupt downstream signaling required for actin filament assembly and organization. As FAM130A2 is associated with actin cytoskeleton dynamics, its functional activity would be inhibited as a result of the disrupted signaling. | ||||||
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $41.00 $74.00 $221.00 $247.00 $738.00 $1220.00 | 39 | |
Paclitaxel stabilizes microtubules and prevents their disassembly, which can impede cell division and intracellular transport. Because FAM130A2 is involved in cytoskeletal dynamics, the microtubule-stabilizing effect of Paclitaxel may indirectly inhibit FAM130A2 by disrupting the dynamic state of microtubules necessary for its function. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $59.00 $85.00 $143.00 $247.00 | 38 | |
Nocodazole disrupts microtubule polymerization, leading to cell cycle arrest and interference with microtubule-dependent processes. This action can inhibit the function of FAM130A2 by impeding the proper organization and dynamics of the cytoskeleton, which FAM130A2 is known to be associated with. | ||||||
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
Cytochalasin D binds to the barbed ends of actin filaments, preventing polymerization and elongation. This directly impacts actin filament organization, a process with which FAM130A2 is involved, thus functionally inhibiting FAM130A2 by disrupting the cytoskeletal structure it helps to regulate. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A binds to actin monomers and prevents their polymerization, which affects cell motility and structure. By disrupting actin filament formation, this compound can indirectly inhibit the functional role of FAM130A2 in cytoskeletal dynamics. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $100.00 $321.00 $2289.00 $4484.00 $18207.00 $34749.00 | 3 | |
Colchicine binds tubulin, preventing its polymerization into microtubules. This disrupts microtubule-dependent processes and can lead to the inhibition of FAM130A2 function, which is dependent on an intact and dynamic cytoskeletal framework. | ||||||
(±)-Blebbistatin | 674289-55-5 | sc-203532B sc-203532 sc-203532A sc-203532C sc-203532D | 5 mg 10 mg 25 mg 50 mg 100 mg | $183.00 $313.00 $464.00 $942.00 $1723.00 | 7 | |
Blebbistatin is an inhibitor of myosin II ATPase activity, which is crucial for muscle contraction and cell motility. By inhibiting myosin II, Blebbistatin can impair cellular structures that rely on myosin for maintenance and function, potentially inhibiting FAM130A2's role in cytoskeletal organization and cell motility. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML-7 is an inhibitor of myosin light chain kinase (MLCK), which is involved in the regulation of the actin-myosin cytoskeleton. Inhibition of MLCK could hinder the phosphorylation of myosin light chains, thereby affecting cytoskeletal dynamics and potentially inhibiting the function of FAM130A2 in cell structure and motility. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), which plays a significant role in actin cytoskeleton organization and cell motility. By inhibiting ROCK, Y-27632 can disrupt cytoskeletal dynamics and cell adhesion, leading to the functional inhibition of FAM130A2, which is implicated in similar cellular processes. | ||||||