FADD Inhibitors
FADD, or Fas-associated death domain protein, serves as a critical adaptor molecule in apoptotic signaling pathways. Its primary function revolves around mediating the transduction of death receptor signals to downstream apoptotic effectors. Upon activation of death receptors such as Fas and TNF receptor 1 (TNFR1), FADD becomes recruited to the receptor complex through interactions between its death domain and the death domain of the receptor. Subsequently, FADD facilitates the assembly of the death-inducing signaling complex (DISC), wherein it binds to procaspase-8 or procaspase-10 via its death effector domain (DED). This recruitment of procaspases leads to their activation through proximity-induced autoactivation, initiating the caspase cascade and ultimately resulting in apoptosis. Beyond its role in death receptor-mediated apoptosis, FADD also participates in other signaling pathways, including those mediated by Toll-like receptors and DNA damage response pathways, highlighting its multifaceted functions in cellular homeostasis and immune regulation.
Inhibition of FADD primarily focuses on disrupting its interactions within the apoptotic signaling cascade, thereby impeding its ability to transmit apoptotic signals. Various approaches have been explored to target FADD inhibition, including the development of small molecules or peptides that interfere with the interactions between FADD and death receptors or procaspases. Additionally, strategies aimed at blocking the recruitment of FADD to the DISC or disrupting its downstream signaling events have been investigated as avenues for FADD inhibition. Moreover, modulation of upstream regulators or downstream effectors of FADD signaling pathways may indirectly impact FADD function, offering alternative routes for inhibition. By elucidating the intricate mechanisms underlying FADD-mediated apoptosis and exploring diverse strategies for its inhibition, researchers aim to gain insights into the regulation of cell death processes and uncover novel avenues for intervention in pathological conditions associated with dysregulated apoptosis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, a polyphenolic compound, indirectly inhibits FADD by modulating signaling pathways like NF-κB and MAPK. It downregulates pro-survival factors and inhibits inflammatory cascades, impacting FADD-mediated cellular responses related to apoptosis and survival. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
Celastrol, a triterpenoid compound, acts as an FADD inhibitor by targeting the NF-κB pathway. Inhibition of IKKβ and suppression of NF-κB activation disrupt FADD expression and function, impacting cellular responses related to inflammation and apoptosis. | ||||||
2-Methoxyestradiol | 362-07-2 | sc-201371 sc-201371A | 10 mg 50 mg | $71.00 $288.00 | 6 | |
2-Methoxyestradiol, a derivative of estradiol, serves as an FADD inhibitor by affecting the PI3K/Akt pathway. Inhibition of Akt activation indirectly modulates FADD expression and function, disrupting cellular responses related to apoptosis and survival. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Bay 11-7082 is a pharmacological inhibitor that targets FADD indirectly by inhibiting the NF-κB pathway. Suppression of IKKβ disrupts NF-κB activation, influencing FADD expression and function, altering cellular responses related to inflammation and apoptosis. | ||||||
Gossypol | 303-45-7 | sc-200501 sc-200501A | 25 mg 100 mg | $116.00 $230.00 | 12 | |
Gossypol, a natural compound found in cottonseeds, serves as an FADD inhibitor by impacting the Bcl-2 family of proteins. Antagonizing anti-apoptotic Bcl-2 proteins indirectly influences FADD-mediated apoptotic signaling. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $81.00 $306.00 | 32 | |
Parthenolide, a sesquiterpene lactone, acts as an FADD inhibitor by targeting the NF-κB pathway. Inhibition of IKKβ disrupts NF-κB activation, influencing FADD expression and function, impacting cellular responses related to inflammation and apoptosis. | ||||||
Piperlongumine | 20069-09-4 | sc-364128 | 10 mg | $107.00 | ||
Piperlongumine serves as an FADD inhibitor by influencing redox signaling pathways. Induction of oxidative stress indirectly modulates FADD expression and function, disrupting cellular responses related to apoptosis and survival. | ||||||
Auranofin | 34031-32-8 | sc-202476 sc-202476A sc-202476B | 25 mg 100 mg 2 g | $153.00 $214.00 $4000.00 | 39 | |
Auranofin, a gold-containing compound, acts as an FADD inhibitor by targeting redox signaling pathways. Induction of oxidative stress indirectly modulates FADD expression and function, disrupting cellular responses related to apoptosis and survival. | ||||||
Obatoclax Mesylate | 803712-79-0 | sc-364221 sc-364221A | 5 mg 10 mg | $96.00 $141.00 | ||
Obatoclax, a small-molecule inhibitor, serves as an FADD inhibitor by targeting the Bcl-2 family of proteins. Inhibition of anti-apoptotic Bcl-2 proteins indirectly influences FADD-mediated apoptotic signaling. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
Withaferin A, a steroidal lactone, serves as an FADD inhibitor by targeting the NF-κB pathway. Inhibition of IKKβ disrupts NF-κB activation, influencing FADD expression and function, altering cellular responses related to inflammation and apoptosis. | ||||||