Date published: 2025-11-22

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Factor IX Inhibitors

The chemical class of Factor IX Inhibitors primarily encompasses compounds that either directly inhibit the activity of Factor IX or influence the coagulation cascade in which Factor IX plays a crucial role. These inhibitors are not exclusively targeting Factor IX but often work by modulating the activity of other factors in the coagulation pathway, thereby indirectly affecting Factor IX function. For instance, Rivaroxaban, Apixaban, and Edoxaban are direct inhibitors of Factor Xa, a key enzyme activated by Factor IX in the coagulation cascade. Their action results in the indirect modulation of Factor IX activity. In contrast, compounds like Warfarin work by inhibiting the synthesis of vitamin K-dependent clotting factors, including Factor IX, thereby reducing its functional availability in the coagulation process. Similarly, Heparin and its derivatives, such as Dalteparin and Enoxaparin, enhance the activity of antithrombin III, which indirectly diminishes the effectiveness of Factor IX in clot formation.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

GGACK

65113-67-9sc-201314
sc-201314A
sc-201314B
5 mg
25 mg
100 mg
$315.00
$1375.00
$5000.00
(1)

GGACK functions as a potent acid halide, showcasing remarkable selectivity in its interactions with nucleophiles. Its unique structural features facilitate the formation of transient acyl-enzyme complexes, which can significantly alter reaction dynamics. The compound's electron-withdrawing characteristics enhance its reactivity, allowing for efficient acylation processes. Additionally, GGACK's steric hindrance plays a crucial role in dictating the orientation and outcome of its chemical transformations.

Rivaroxaban

366789-02-8sc-208311
2 mg
$155.00
18
(1)

Directly inhibits Factor Xa, an enzyme in the coagulation cascade downstream of Factor IX.

Apixaban

503612-47-3sc-364406
sc-364406A
10 mg
50 mg
$235.00
$622.00
2
(1)

Inhibits Factor Xa, which is activated by Factor IX in the coagulation pathway.

Edoxaban

480449-70-5sc-483508
25 mg
$522.00
(0)

Targets Factor Xa, indirectly influencing the activity of Factor IX.

Fondaparinux

104993-28-4sc-507424
10 mg
$297.00
(0)

Enhances the inhibition of Factor Xa, indirectly affecting Factor IX mediated reactions.

Argatroban

74863-84-6sc-201310
sc-201310A
10 mg
50 mg
$115.00
$460.00
13
(1)

Direct thrombin inhibitor, indirectly affecting Factor IX's role in clot formation.

Bivalirudin

128270-60-0sc-278793
5 mg
$110.00
(0)

Directly inhibits thrombin, thereby indirectly influencing Factor IX activity.

Dabigatran

211914-51-1sc-481166
5 mg
$205.00
1
(0)

Inhibits thrombin, affecting the downstream effects of Factor IX activation.

Warfarin

81-81-2sc-205888
sc-205888A
1 g
10 g
$72.00
$162.00
7
(1)

Inhibits synthesis of vitamin K-dependent clotting factors, including Factor IX.

Vitamin K1

84-80-0sc-280189
sc-280189A
1 g
5 g
$79.00
$163.00
(0)

Essential for the carboxylation of Factor IX, its deficiency can reduce Factor IX function.