Exportin 4 Activators
The potential activators of Exportin 4 (XPO4) are understood to be various compounds that might exert their influence indirectly by impacting the cellular mechanisms or pathways related to its function. Given the essential role of XPO4 in nuclear-cytoplasmic transport, particularly for eIF5A and other cargoes, alterations in the broader landscape of nuclear export can significantly affect its activity. Compounds such as Leptomycin B, though primarily an inhibitor of CRM1/exportin 1, might lead to compensatory or adaptive changes in the cellular transport mechanisms, potentially affecting XPO4 activity indirectly. Similarly, agents like Rapamycin and Selinexor, known for their roles in mTOR inhibition and nuclear export respectively, could influence the demand or regulation of XPO4 by altering cellular growth conditions or export dynamics.
Moreover, chemicals such as Trichostatin A and Geldanamycin, which target histone deacetylases and HSP90 respectively, could influence the expression or stability of proteins involved in or regulated by XPO4. This indirect modulation might result from changes in gene expression patterns or protein stability, affecting the transport efficiency or cargo selection of XPO4. Proteasome inhibitors like Bortezomib and MG132 further illustrate the complexity of intracellular regulation, potentially affecting XPO4 by altering protein degradation pathways, thereby impacting the balance of nuclear-cytoplasmic transport. Similarly, Cycloheximide's role in inhibiting protein biosynthesis might lead to altered levels of XPO4's interacting proteins or cargoes, indirectly affecting its transport activity. Furthermore, agents like Mitoxantrone, Retinoic Acid, and Actinomycin D, known for their impact on DNA replication, repair mechanisms, and RNA polymerase respectively, might also influence XPO4 activity. By altering the cellular demand for nuclear export in response to stress, DNA damage, or changes in gene expression, these compounds might indirectly modulate the function of XPO4. Collectively, these potential indirect activators, through their diverse effects on cellular pathways and regulatory mechanisms, underscore the complex nature of modulating nuclear export processes and highlight the intricacies of influencing transporter activity like that of XPO4, integral to cellular homeostasis and response mechanisms.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Leptomycin B | 87081-35-4 | sc-358688 sc-358688A sc-358688B | 50 µg 500 µg 2.5 mg | $105.00 $408.00 $1224.00 | 35 | |
While known as an inhibitor of CRM1/exportin 1, Leptomycin B's role in nuclear export might indirectly affect the function or regulation of XPO4 by altering the cellular balance of nuclear-cytoplasmic transport, potentially influencing compensatory mechanisms. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
As an mTOR inhibitor, Rapamycin can influence cellular growth and proliferation, indirectly affecting the demand or regulation of nuclear export pathways including XPO4, particularly under stress or in proliferating cells. | ||||||
KPT 330 | 1393477-72-9 | sc-489062 | 5 mg | $170.00 | ||
Known as an inhibitor of XPO1, Selinexor's impact on nuclear export might lead to altered cellular reliance on other exportins like XPO4, potentially influencing its activity or expression indirectly. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
As an inhibitor of histone deacetylases, Trichostatin A might influence gene expression patterns including those related to nuclear transporters such as XPO4, potentially modifying its expression or function indirectly. | ||||||
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
By inhibiting heat shock protein 90 (HSP90), Geldanamycin may affect the stability and function of various client proteins, potentially including those involved in or regulated by XPO4, indirectly affecting its activity. | ||||||
Bortezomib | 179324-69-7 | sc-217785 sc-217785A | 2.5 mg 25 mg | $132.00 $1064.00 | 115 | |
As a proteasome inhibitor, Bortezomib could indirectly affect XPO4 activity by influencing the degradation pathway of proteins, including possibly XPO4 itself or its cargo proteins, altering nuclear export dynamics. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
Similar to Geldanamycin, as an HSP90 inhibitor, 17-AAG may affect client proteins of HSP90 that are involved in or regulated by nuclear export processes, potentially influencing XPO4 activity indirectly. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that can indirectly affect XPO4 by altering the degradation of nuclear export signaling proteins or adaptors, possibly affecting the overall nuclear export process including the function of XPO4. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
As an inhibitor of protein biosynthesis, Cycloheximide could indirectly affect XPO4 function by altering the levels of proteins that interact with or are transported by XPO4, impacting its activity. | ||||||
Mitoxantrone | 65271-80-9 | sc-207888 | 100 mg | $279.00 | 8 | |
As an antineoplastic agent, Mitoxantrone affects DNA replication and repair mechanisms. It might indirectly affect XPO4 by altering cellular demand for nuclear export during stress responses related to DNA damage. | ||||||