ELOVL6 Activators
ELOVL6 Activators encompass a range of chemical compounds that collectively enhance the functional activity of ELOVL6, a key enzyme in the elongation of long-chain saturated and monounsaturated fatty acids. Substrates such as Palmitic Acid and Oleic Acid directly stimulate ELOVL6's elongation function by providing the necessary fatty acid chains for elongation. Similarly, Stearoyl-CoA, a direct substrate, plays a pivotal role in enhancing ELOVL6 activity. These substrates are crucial for the enzymatic action of ELOVL6, ensuring its involvement in the elongation process. Furthermore, Acetyl-CoA and Malonyl-CoA, central metabolites in fatty acid synthesis, indirectly contribute to ELOVL6 function by supplying the acetyl and malonyl groups, respectively, essential for the elongation process. NADPH, providing the reducing power necessary for fatty acid elongation, further supports the function of ELOVL6, showcasing the interplay between various metabolic components and ELOVL6 activity.
In addition to these substrates and cofactors, hormonal regulators such as Insulin and Leptin indirectly modulate ELOVL6 activity. Insulin, by upregulating ELOVL6 expression, enhances its activity in lipogenesis, while Leptin, involved in energy balance, can influence lipid metabolism and thereby modulate ELOVL6 expression. Thiazolidinediones, by increasing insulin sensitivity, also contribute to the upregulation of ELOVL6 in lipogenic pathways. The role of Glucose in promoting lipogenesis underlines the importance of energy availability in regulating ELOVL6 activity. Moreover, Choline and Ethanolamine, involved in lipid metabolism and phospholipid synthesis, respectively, indirectly enhance ELOVL6 activity by contributing to processes that utilize the elongated fatty acids produced by ELOVL6. These activators, through their varied roles in substrate provision, hormonal regulation, and metabolic integration, collectively enhance the activity of ELOVL6, underscoring its critical function in fatty acid elongation and lipid metabolism.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Palmitic Acid | 57-10-3 | sc-203175 sc-203175A | 25 g 100 g | $114.00 $286.00 | 2 | |
Palmitic Acid, a saturated fatty acid, can enhance ELOVL6 activity by serving as a substrate for the elongation process. ELOVL6 catalyzes the elongation of long-chain saturated and monounsaturated fatty acids, and the presence of palmitic acid can directly increase its functional activity. | ||||||
Oleic Acid | 112-80-1 | sc-200797C sc-200797 sc-200797A sc-200797B | 1 g 10 g 100 g 250 g | $37.00 $104.00 $580.00 $1196.00 | 10 | |
Oleic Acid, a monounsaturated fatty acid, indirectly enhances ELOVL6 activity by acting as a substrate. ELOVL6 extends monounsaturated fatty acids, and oleic acid availability can directly stimulate ELOVL6's elongation function. | ||||||
β-Nicotinamide adenine dinucleotide phosphate | 53-59-8 | sc-215560 sc-215560A | 100 mg 250 mg | $182.00 $319.00 | ||
NADPH, a cofactor in reductive biosynthesis, indirectly enhances ELOVL6 activity by providing the reducing power necessary for the elongation of fatty acids, thereby facilitating ELOVL6 function. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin, a hormone regulating metabolism, indirectly enhances ELOVL6 activity by upregulating its expression. Insulin promotes lipogenesis, and ELOVL6, being a part of this pathway, is upregulated, leading to increased fatty acid elongation activity. | ||||||
D(+)Glucose, Anhydrous | 50-99-7 | sc-211203 sc-211203B sc-211203A | 250 g 5 kg 1 kg | $38.00 $198.00 $65.00 | 5 | |
Glucose, as a primary energy source, indirectly enhances ELOVL6 activity by promoting lipogenesis under conditions of high energy availability, thereby potentially increasing ELOVL6 expression and its fatty acid elongation activity. | ||||||
Choline chloride | 67-48-1 | sc-207430 sc-207430A sc-207430B | 10 mg 5 g 50 g | $33.00 $37.00 $52.00 | 1 | |
Choline, involved in lipid metabolism, indirectly enhances ELOVL6 activity by contributing to the formation of VLDL, which is important for transporting the products of ELOVL6 activity, thus potentially increasing the efficiency of ELOVL6's elongation process. | ||||||
Ethanolamine | 141-43-5 | sc-203042 sc-203042A sc-203042B | 25 ml 500 ml 2.5 L | $22.00 $56.00 $204.00 | 1 | |
Ethanolamine, involved in phospholipid synthesis, can indirectly enhance ELOVL6 activity. It participates in the synthesis of phospholipids which incorporate elongated fatty acids produced by ELOVL6, thereby potentially increasing the demand for ELOVL6's enzymatic activity. | ||||||