EID-3 Activators
EID-3, or EP300 Interacting Inhibitor of Differentiation 3, belongs to a group of proteins that interact with EP300 (E1A binding protein p300), a well-known transcriptional co-activator involved in regulating gene expression across numerous cellular processes including differentiation, proliferation, and apoptosis. EID-3 functions primarily as a modulator of transcription by influencing the activity of EP300, which itself acts by acetylating histones and thereby modifying chromatin structure to control gene expression. This interaction suggests that EID-3 plays a significant role in the regulation of genes that are crucial for cellular differentiation processes. By modulating EP300 activity, EID-3 may act to inhibit or delay differentiation, thereby maintaining cells in a more proliferative, undifferentiated state which is vital during embryonic development and in tissue regeneration scenarios.
The activation of EID-3 is crucial for its function and can be influenced by several biochemical pathways and cellular signals. One primary mechanism likely involves the phosphorylation of EID-3, which can enhance its interaction with EP300 or affect its ability to modulate the transcriptional activity of EP300. Phosphorylation typically occurs in response to upstream signaling events triggered by growth factors, hormones, or other extracellular signals that dictate cell behavior in response to environmental cues. Such modification not only regulates EID-3's activity but also its stability and localization within the cell, factors that are critical for its function as a transcriptional modulator. Furthermore, the expression of EID-3 itself can be subject to regulation at the transcriptional level, where specific transcription factors upregulate or downregulate its gene expression in response to developmental cues or cellular stress signals. This transcriptional control ensures that EID-3 is available in appropriate amounts when needed to interact with EP300 and affect cellular differentiation processes effectively.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
A potent and selective p300/CBP catalytic inhibitor. By downregulating the activity of EP300, A-485 may modulate the cellular context where EID-3 functions, as EID-3 can interact with EP300 in transcriptional regulation processes. | ||||||
SGC-CBP30 | 1613695-14-9 | sc-473871 sc-473871A | 5 mg 10 mg | $178.00 $338.00 | ||
A CBP/p300 bromodomain inhibitor. This compound affects the bromodomains of EP300 and, by doing so, indirectly modifies the interaction dynamics of associated proteins, including EID-3, within the EP300 signaling framework. | ||||||
TG101348 | 936091-26-8 | sc-364740 sc-364740A | 5 mg 25 mg | $207.00 $515.00 | 6 | |
TG101348 is a JAK2 inhibitor. Given that EP300 can be implicated in JAK-STAT signaling, by inhibiting JAK2, this compound indirectly affects the downstream targets of the pathway, including potentially EID-3, if it's involved in this signaling cascade. | ||||||
Epz004777 | 1338466-77-5 | sc-507560 | 100 mg | $575.00 | ||
A DOT1L inhibitor. DOT1L interacts with EP300 in various cellular processes. By inhibiting DOT1L, this compound can indirectly modulate the interaction dynamics of EP300, which may have repercussions for associated proteins like EID-3. | ||||||
9-[5-Deoxy-5-[[cis-3-[2-[6-(1,1-dimethylethyl)-1H-benzimidazol-2-yl]ethyl]cyclobutyl](1-methylethyl)amino]-β-D-ribofuranosyl]-9H-purin-6-amine | 1380288-87-8 | sc-500607 | 50 mg | $13500.00 | ||
Another DOT1L inhibitor. As DOT1L and EP300 have interaction points, the inhibition of DOT1L by EPZ-5676 may alter the function of EP300 and, in turn, have indirect implications for proteins like EID-3 within the EP300 framework. | ||||||
CCT241533 | 1262849-73-9 | sc-507308 | 10 mg | $440.00 | ||
A CHK2 kinase inhibitor. CHK2 is involved in pathways where EP300 plays a role. By inhibiting CHK2, CCT241533 indirectly affects the downstream cellular processes involving EP300 and proteins like EID-3 that might be associated with EP300. | ||||||