EG546638 Activators

Ube2d4, known as ubiquitin-conjugating enzyme E2D 4, plays a crucial role in the regulation of protein ubiquitination. Predicted to enable ubiquitin conjugating enzyme activity, it is anticipated to act upstream of or within protein ubiquitination processes. The intricate network of chemical activators revealed in the table showcases diverse pathways and mechanisms influencing Ube2d4 activation. Pyrvinium Pamoate targets Wnt/β-catenin signaling, whereas Dorsomorphin modulates the AMPK/mTOR pathway, indirectly stimulating Ube2d4. Nordihydroguaiaretic Acid, through the Nrf2-Keap1 pathway, and SB202190, via p38 MAPK inhibition, also contribute to Ube2d4 activation by influencing associated cellular processes.

Ruxolitinib, BAY 11-7082, and Perifosine act as indirect activators through the JAK/STAT, NF-κB, and PI3K/Akt pathways, respectively. Furthermore, 6-Aminonicotinamide disrupts the NAD+/SIRT1/AMPK axis, and TAK-242 influences the TLR4/NF-κB pathway, both indirectly enhancing Ube2d4 activity. Brefeldin A, by disturbing ER-to-Golgi transport, alters the ER stress and UPR pathways, contributing to Ube2d4 activation. Finally, AZD5363 modulates the PI3K/AKT/mTOR signaling cascade, indirectly activating Ube2d4. This diverse array of chemical modulators offers insights into potential strategies for manipulating Ube2d4 function within specific cellular contexts.