EG434008 Activators
Tmem178b, a transmembrane protein predominantly expressed in the dorsal root ganglion and spinal cord, emerges as a key player in membrane-associated activities. Its known and predicted functions underscore its involvement in crucial cellular processes within the neural tissues. Tmem178b's activation is modulated by a diverse array of chemicals, each with distinct modes of action, ultimately converging on pathways that govern its expression and engagement in membrane-associated functions. The presented chemicals, acting as either direct or indirect activators of Tmem178b, exemplify the intricate regulatory network governing the protein's activation. Retinoic acid, for instance, directly activates Tmem178b by influencing the retinoic acid receptor signaling pathway, promoting its engagement in membrane-associated activities. Lithium chloride, an indirect activator, modulates the Wnt/β-catenin pathway to enhance Tmem178b expression and contribute to its role in neural tissues. Forskolin stimulates the cAMP/PKA pathway, leading to direct activation and supporting Tmem178b's involvement in membrane-associated functions.
Dexamethasone, N-Acetylcysteine, tauroursodeoxycholic acid, butyrate, 2-deoxy-D-glucose, sulforaphane, PMA, AICAR, and apigenin each play a role in Tmem178b activation, contributing to the protein's engagement in neural tissues. The comprehensive understanding of these activation mechanisms opens avenues for further exploration of Tmem178b's role in membrane-associated activities and its implications in neural function. This intricate interplay between specific chemicals and pathways sheds light on potential strategies for manipulating Tmem178b activation, offering valuable insights for future research into its physiological functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid serves as a direct activator of Tmem178b by influencing the retinoic acid receptor (RAR) signaling pathway. It up-regulates Tmem178b expression through RAR activation, promoting its engagement in membrane-associated activities within the dorsal root ganglion and spinal cord. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride acts as an indirect activator of Tmem178b through the Wnt/β-catenin pathway. By inhibiting GSK-3β, it enhances β-catenin stability, leading to increased Tmem178b expression and subsequent activation, contributing to membrane-associated functions in the dorsal root ganglion and spinal cord. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone acts as an indirect activator of Tmem178b by modulating the glucocorticoid receptor (GR) pathway. By activating GR, it promotes Tmem178b expression, leading to increased protein levels and subsequent engagement in membrane-associated activities within the dorsal root ganglion and spinal cord. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine serves as an indirect activator of Tmem178b through the Nrf2 pathway. By promoting Nrf2 translocation, it enhances the transcription of Tmem178b, leading to increased protein levels and subsequent activation, supporting membrane-associated functions in the dorsal root ganglion and spinal cord. | ||||||
Tauroursodeoxycholic Acid, Sodium Salt | 14605-22-2 | sc-281165 | 1 g | $644.00 | 5 | |
Tauroursodeoxycholic acid functions as a direct activator of Tmem178b by influencing the ERK/MAPK pathway. It enhances ERK phosphorylation, leading to increased Tmem178b expression and subsequent activation, contributing to membrane-associated activities within the dorsal root ganglion and spinal cord. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as an indirect activator of Tmem178b through the HDAC inhibition pathway. By inhibiting HDAC activity, it promotes the acetylation of histones, leading to increased Tmem178b expression and subsequent activation, supporting membrane-associated functions in the dorsal root ganglion and spinal cord. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose functions as a direct activator of Tmem178b by influencing the AMPK pathway. It enhances AMPK phosphorylation, leading to increased Tmem178b expression and subsequent activation, supporting its role in membrane-associated activities within the dorsal root ganglion and spinal cord. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane serves as an indirect activator of Tmem178b through the Keap1/Nrf2 pathway. By promoting Nrf2 translocation, it enhances Tmem178b transcription, leading to increased protein levels and subsequent activation, contributing to membrane-associated functions in the dorsal root ganglion and spinal cord. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA functions as a direct activator of Tmem178b by influencing the PKC pathway. It activates PKC, promoting Tmem178b expression and subsequent up-regulation, supporting its role in membrane-associated activities within the dorsal root ganglion and spinal cord. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $60.00 $270.00 $350.00 | 48 | |
AICAR serves as a direct activator of Tmem178b by stimulating the AMPK pathway. It enhances AMPK phosphorylation, leading to increased Tmem178b expression and subsequent activation, contributing to membrane-associated functions within the dorsal root ganglion and spinal cord. | ||||||