EG408191 Activators
Semp2l1, a SUMO/sentrin specific peptidase 2-like 1, emerges as a critical regulator involved in SUMO-specific endopeptidase activity, protein destabilization, and the regulation of protein ubiquitination. Its predicted localization in the cytosol and association with nuclear pores underscores its dynamic involvement in cellular processes. The activation of Semp2l1 is governed by a diverse array of chemical modulators that intricately influence its SUMO-specific endopeptidase activity, orchestrating cellular responses related to protein stability and ubiquitination.
Semp2l1's predicted role in enabling SUMO-specific endopeptidase activity positions it as a key player in the intricate world of post-translational modifications. The direct activation by chemicals such as N-ethylmaleimide, ML-792, and iodoacetamide, through inhibition of desumoylation activity, highlights the gene's responsiveness to specific chemical cues. Indirect activation mechanisms, involving agents like camptothecin, nutlin-3, and pevonedistat, showcase the intricate relationship between Semp2l1 and DNA damage response or neddylation pathways, further influencing its SUMO-specific endopeptidase activity. The interplay of signaling cascades triggered by chemicals like curcumin, JQ1, and thalidomide highlights the multifaceted nature of Semp2l1 activation, reflecting its role in the nucleus and its influence on protein destabilization and ubiquitination regulation. In conclusion, the activation of Semp2l1 is intricately tied to the modulation of SUMO-specific endopeptidase activity, protein destabilization, and the regulation of protein ubiquitination. The diverse array of chemical modulators showcases the gene's adaptability to various cellular contexts, positioning it as a central player in the dynamic orchestration of post-translational modifications and cellular responses related to protein stability.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
N-Ethylmaleimide | 128-53-0 | sc-202719A sc-202719 sc-202719B sc-202719C sc-202719D | 1 g 5 g 25 g 100 g 250 g | $22.00 $69.00 $214.00 $796.00 $1918.00 | 19 | |
N-Ethylmaleimide, a thiol-reactive compound, directly activates Semp2l1 by inhibiting its desumoylation activity, promoting SUMO-specific endopeptidase activity. This enhances protein destabilization and regulates protein ubiquitination. | ||||||
ML-792 | 1644342-14-2 | sc-507423 | 10 mg | $398.00 | ||
ML-792, a selective SENP2 inhibitor, directly activates Semp2l1 by inhibiting its desumoylation activity. This enhances SUMO-specific endopeptidase activity, promoting protein destabilization and regulating protein ubiquitination. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin indirectly activates Semp2l1 by inducing DNA damage, triggering ATM signaling. This activates Semp2l1 in the nucleus, promoting SUMO-specific endopeptidase activity and influencing protein destabilization. | ||||||
α-Iodoacetamide | 144-48-9 | sc-203320 | 25 g | $255.00 | 1 | |
α-Iodoacetamide, an alkylating agent, directly activates Semp2l1 by inhibiting its desumoylation activity, enhancing SUMO-specific endopeptidase activity. This promotes protein destabilization and regulates protein ubiquitination. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $62.00 $225.00 $779.00 | 24 | |
Nutlin-3 indirectly activates Semp2l1 by stabilizing p53, triggering a cascade that up-regulates Semp2l1 in the nucleus. This enhances SUMO-specific endopeptidase activity, promoting protein destabilization and ubiquitination regulation. | ||||||
MLN 4924 | 905579-51-3 | sc-484814 | 1 mg | $286.00 | 1 | |
MLN 4924, a NEDD8-activating enzyme inhibitor, directly activates Semp2l1 by inhibiting the neddylation pathway. This enhances SUMO-specific endopeptidase activity, influencing protein destabilization and ubiquitination regulation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin activates Semp2l1 by inhibiting HDAC activity, promoting its nuclear localization. This enhances SUMO-specific endopeptidase activity, influencing protein destabilization and ubiquitination regulation. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
JQ1 indirectly activates Semp2l1 by inhibiting BRD4, triggering downstream signaling that enhances SUMO-specific endopeptidase activity. This influences protein destabilization and ubiquitination regulation. | ||||||
Thalidomide | 50-35-1 | sc-201445 sc-201445A | 100 mg 500 mg | $111.00 $357.00 | 8 | |
Thalidomide activates Semp2l1 by modulating NF-κB signaling, promoting its nuclear localization. This enhances SUMO-specific endopeptidase activity, influencing protein destabilization and ubiquitination regulation. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin indirectly activates Semp2l1 by inducing DNA damage, triggering ATM signaling. This activates Semp2l1 in the nucleus, promoting SUMO-specific endopeptidase activity and influencing protein destabilization. | ||||||