Ect2 Inhibitors
Ect2 inhibitors constitute a diverse array of compounds that target various components of the signaling pathways and cellular processes regulated by Ect2. These inhibitors play a crucial role in elucidating the intricate mechanisms of Ect2-mediated cellular functions and provide avenues for research. One prominent class of Ect2 inhibitors includes small molecules such as EHT 1864, which directly targets the Rho family GTPase and disrupts Ect2-mediated GTPase activation. Additionally, Y-27632, Thiazovivin, and Citron Kinase Inhibitor indirectly modulate Ect2 by inhibiting Rho-associated protein kinase (ROCK) or Citron kinase, interfering with phosphorylation events critical for Ect2 activation. C3 Transferase, an exoenzyme, ADP-ribosylates and inactivates Rho GTPases, including those regulated by Ect2, disrupting the normal signaling cascades involved in cytokinesis.
Another class of inhibitors includes compounds like NSC 23766 and ML141, targeting downstream effectors like Rac1 and Cdc42, respectively. By inhibiting these effectors, these compounds disrupt the signaling pathways controlled by Ect2, ultimately inhibiting cytokinesis and cell division. Rhosin specifically targets RhoA, a key GTPase regulated by Ect2, further expanding the repertoire of Ect2 inhibitors. Furthermore, compounds like Secramine A and Latrunculin A interfere with the proper localization and function of Ect2 during mitosis by disrupting the central spindle and actin dynamics, respectively. This multifaceted approach to targeting different aspects of Ect2 regulation allows researchers to dissect the specific contributions of Ect2 in cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
EHT 1864 | 754240-09-0 | sc-361175 sc-361175A | 10 mg 50 mg | $213.00 $889.00 | 12 | |
EHT 1864 is a small molecule inhibitor that directly targets the Rho family GTPase, inhibiting its activation and thereby impeding Ect2-mediated GTPase activation. The inhibition of Ect2's Rho GTPase activating protein (GAP) activity disrupts its role in cytokinesis, leading to cell cycle arrest and suppression of cell proliferation. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Y-27632 is a selective inhibitor of Rho-associated protein kinase (ROCK), which indirectly modulates Ect2 by preventing its phosphorylation. By inhibiting ROCK, Y-27632 reduces the phosphorylation of Ect2 and interferes with its activation, thereby impeding cytokinesis and cell division. | ||||||
Rhosin | 1173671-63-0 | sc-507401 | 25 mg | $555.00 | ||
Rhosin is a selective inhibitor of RhoA, a key GTPase regulated by Ect2. By blocking RhoA activation, Rhosin disrupts the downstream signaling events mediated by Ect2, ultimately inhibiting cytokinesis and cell proliferation. | ||||||
Thiazovivin | 1226056-71-8 | sc-361380 sc-361380A | 10 mg 25 mg | $284.00 $634.00 | 15 | |
Thiazovivin is a selective inhibitor of Rho-associated protein kinase (ROCK) that indirectly modulates Ect2 by preventing its phosphorylation. By inhibiting ROCK, Thiazovivin reduces the phosphorylation of Ect2 and interferes with its activation, thereby impeding cytokinesis and cell division. | ||||||
ML 141 | 71203-35-5 | sc-362768 sc-362768A | 5 mg 25 mg | $137.00 $512.00 | 7 | |
ML141 is a selective Cdc42 inhibitor, a Rho GTPase regulated by Ect2. By inhibiting Cdc42, ML141 disrupts the downstream signaling events controlled by Ect2, ultimately leading to the inhibition of cytokinesis and cell proliferation. | ||||||
GGTI 298 | 1217457-86-7 | sc-361184 sc-361184A | 1 mg 5 mg | $193.00 $838.00 | 2 | |
GGTI-298 is a geranylgeranyltransferase I (GGTase I) inhibitor that indirectly influences Ect2 by preventing the geranylgeranylation of Rho GTPases. By inhibiting the prenylation of Rho GTPases, including those regulated by Ect2, GGTI-298 disrupts their membrane localization and downstream signaling, leading to the inhibition of Ect2-mediated cellular processes. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Latrunculin A is a toxin that disrupts actin dynamics by sequestering actin monomers, indirectly modulating Ect2 by interfering with the actin cytoskeleton. By disrupting actin dynamics, Latrunculin A hinders the proper localization and function of Ect2 during cytokinesis, leading to the inhibition of cell division. | ||||||