E430002G05Rik Inhibitors
Chemical inhibitors of E430002G05Rik function by interacting with various signaling pathways and molecular processes that are essential for the protein's activity. SB-3CT, for instance, targets matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, which play a role in extracellular matrix remodeling. By inhibiting these MMPs, SB-3CT can reduce the degradation of the extracellular matrix, potentially affecting the signaling pathways that E430002G05Rik is part of. Along a similar vein, PD 98059 and U0126 act upon the MAPK/ERK pathway by inhibiting MEK, which is instrumental in cell signaling related to proliferation and differentiation. The inhibition by these chemicals can suppress the pathway's activity, leading to a decrease in E430002G05Rik-related functions.
Other inhibitors, such as LY294002 and Wortmannin, exert their effects by inhibiting phosphatidylinositol 3-kinase (PI3K), a key player in growth and survival signaling pathways. The suppression of PI3K activity by these inhibitors can lead to a decrease in the functional activity of E430002G05Rik if it is involved in PI3K-dependent processes. SP600125, by inhibiting c-Jun N-terminal kinase (JNK), can disrupt cellular processes like apoptosis and inflammation, which may involve E430002G05Rik. SB202190 targets p38 MAP kinase, influencing cell differentiation, apoptosis, and autophagy, which could interfere with E430002G05Rik's role in these processes. GF109203X's inhibition of protein kinase C (PKC) and PP2's inhibition of Src-family tyrosine kinases can also indirectly suppress E430002G05Rik's function by blocking the respective kinases' signal transduction pathways. Lastly, Y-27632 and Dorsomorphin target Rho-associated protein kinase (ROCK) and AMP-activated protein kinase (AMPK) respectively, along with BMP signaling, which can lead to an indirect decrease in E430002G05Rik activity if the protein is associated with pathways regulated by these kinases.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $100.00 $380.00 | 15 | |
SB-3CT is a selective inhibitor of matrix metalloproteinases (MMPs), particularly MMP-2 and MMP-9, which are involved in the degradation of extracellular matrix components. Given that E430002G05Rik may be implicated in cellular processes that are affected by the extracellular matrix remodeling, SB-3CT's inhibition of MMPs can reduce the extracellular matrix degradation, potentially inhibiting the associated signaling pathways and indirectly reducing the functional activity of E430002G05Rik. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a selective inhibitor of the mitogen-activated protein kinase kinase (MEK), which is part of the MAPK/ERK pathway. By inhibiting MEK, PD 98059 suppresses the MAPK/ERK signaling that could contribute to the cellular processes involving E430002G05Rik, thereby indirectly reducing the E430002G05Rik-related activities. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphatidylinositol 3-kinase (PI3K). PI3K signaling is crucial for many cellular processes, including growth and survival. Inhibition of PI3K by LY294002 could lead to a reduction in cellular pathways that E430002G05Rik may be involved in, thereby indirectly inhibiting E430002G05Rik's function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is an inhibitor of MEK1/2, which prevents activation of the ERK1/2 MAP kinase pathway. By inhibiting this pathway, U0126 can suppress cellular processes that could be utilizing E430002G05Rik, thereby indirectly inhibiting the protein's function. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which modulates multiple cellular processes including apoptosis and inflammation. By inhibiting JNK activity, SP600125 could disrupt signal transduction pathways that involve E430002G05Rik, leading to its indirect functional inhibition. | ||||||
SB202190 hydrochloride | 350228-36-3 | sc-222294 sc-222294A | 1 mg 5 mg | $128.00 $495.00 | 13 | |
SB202190 is a potent inhibitor of p38 MAP kinase, which is involved in the regulation of cell differentiation, apoptosis, and autophagy. Through its inhibition of p38 MAP kinase, SB202190 could interfere with signaling pathways that involve E430002G05Rik, leading to its indirect inhibition. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent and irreversible inhibitor of PI3K. It disrupts PI3K-dependent signaling pathways, which may indirectly lead to the inhibition of functions related to E430002G05Rik. | ||||||
Bisindolylmaleimide I (GF 109203X) | 133052-90-1 | sc-24003A sc-24003 | 1 mg 5 mg | $103.00 $237.00 | 36 | |
GF109203X, also known as bisindolylmaleimide I, is a potent and selective inhibitor of protein kinase C (PKC). PKC plays a role in several signal transduction pathways; therefore, GF109203X could indirectly inhibit E430002G05Rik function by blocking PKC-dependent pathways that E430002G05Rik may be involved in. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an inhibitor of the mammalian target of rapamycin (mTOR), which is a central regulator of cell growth and metabolism. Inhibiting mTOR with rapamycin could disrupt processes that are potentially dependent on E430002G05Rik, indirectly inhibiting the protein's function. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $92.00 $223.00 | 30 | |
PP2 is a selective inhibitor of Src-family tyrosine kinases. Src kinases are involved in various signaling pathways that regulate cell proliferation and differentiation. By inhibiting Src kinases, PP2 could indirectly inhibit signaling pathways involving E430002G05Rik. | ||||||