Dynein IC2, axonemal Activators
Dynein IC2, axonemal Activators, refer to a specialized group of chemical compounds specifically tailored to regulate the activity of the motor protein complex known as Dynein IC2, axonemal. This protein is a component of the axonemal dynein complex, which is responsible for the sliding motion of microtubules in cilia and flagella, fundamental for cellular processes like motility, signaling, and fluid movement across epithelial surfaces. Activators of Dynein IC2, axonemal, modulate its function by targeting the ATPase activity that provides the energy for dynein's movement along microtubules. By enhancing this activity, these activators can increase the motility of cilia and flagella, thereby improving the mechanical efficiency of these cellular structures. Some activators work by binding to the dynein complex and facilitating conformational changes that enable the dynein arms to "walk" along the microtubules more effectively. Others may interact with associated regulatory proteins, ensuring that Dynein IC2, axonemal, is in the optimal state for interaction with microtubules and ATP molecules, which is crucial for the generation of mechanical force.
The impact of these activators on the Dynein IC2, axonemal, extends beyond the simple enhancement of dynein's ATPase activity. They may also affect the assembly of the dynein arms onto the microtubules, ensuring that dynein is correctly positioned to generate force. This is particularly important in the context of dynein's role in the beating of cilia and flagella, where precise spatial and temporal control is necessary for proper function. Certain activators may also have secondary effects on the signaling pathways that govern the assembly and maintenance of ciliary and flagellar structures, contributing to a more robust and coordinated activity of Dynein IC2, axonemal. Through these multi-faceted mechanisms, Dynein IC2, axonemal Activators ensure that the motor protein operates at peak efficiency, driving the essential biological processes that rely on active cellular motility. The specificity of these compounds ensures that their action is finely tuned to the dynein complex, thereby enhancing the overall dynamics of microtubule-based motility within the cell.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Paclitaxel stabilizes microtubules and can increase dynein-mediated transport by preventing microtubule disassembly, which is essential for the proper function of Dynein IC2, axonemal. This stabilization can enhance the activity of dynein by providing a more robust track for its motor function. | ||||||
Calmodulin (human), (recombinant) | 73298-54-1 | sc-471287 | 1 mg | $232.00 | ||
Calmodulin, upon calcium binding, can interact with and regulate a variety of protein targets including molecular motors. It could enhance the activity of Dynein IC2, axonemal by affecting its regulation, thus facilitating increased motor activity as a result of improved calcium signaling. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylate cyclase, increasing intracellular cAMP levels. Elevated cAMP can enhance the activity of Dynein IC2, axonemal indirectly by PKA-mediated phosphorylation of associated regulatory proteins, thus potentially increasing the motor activity of dynein. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $89.00 $262.00 | 13 | |
ML-7 inhibits myosin light chain kinase (MLCK), which can indirectly affect cytoskeletal dynamics and cellular processes that may rely on Dynein IC2, axonemal function. By inhibiting MLCK, ML-7 may cause a shift in the cytoskeletal organization favoring dynein motor activity and transport functions. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
Nocodazole disrupts microtubule polymerization. In low concentrations, it may paradoxically enhance the activity of Dynein IC2, axonemal by inducing a compensatory mechanism that increases dynein-based transport to stabilize cell structure, thereby enhancing dynein's functional activity. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic acid is a potent inhibitor of protein phosphatases 1 and 2A. Inhibition of these phosphatases can lead to increased phosphorylation of proteins within the cell. Phosphorylation events can indirectly enhance the activity of Dynein IC2, axonemal by modifying adaptor proteins or dynein regulators, thus influencing dynein motor function. | ||||||
Pentylenetetrazole | 54-95-5 | sc-203345 sc-203345A | 5 g 25 g | $46.00 $97.00 | 2 | |
Pentylenetetrazol is a known GABA receptor antagonist that can enhance neuronal activity. While not directly linked to Dynein IC2, axonemal, increased neuronal activity can indirectly require enhanced axonal transport, which could upregulate dynein motor function due to increased cellular demand. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine can inhibit the enzyme P-glycoprotein, which is involved in multidrug resistance. By inhibiting this enzyme, piperine could enhance intracellular concentrations of various molecules, potentially increasing the cargo load for Dynein IC2, axonemal-mediated transport, thus indirectly enhancing its activity. | ||||||